Molecular Cell Biology

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Authors

Harvey Lodish

HARVEY LODISH is Professor of Biology and Professor of Biological Engineering at the Massachusetts Institute of Technology and a Founding Member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell-membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and TGF–β receptors. His laboratory also studies long noncoding RNAs and microRNAs that regulate the development and function of hematopoietic cells and adipocytes. Dr. Lodish teaches undergraduate and graduate courses in cell biology and biotechnology.

Arnold Berk

ARNOLD BERK holds the UCLA Presidential Chair in Molecular Cell Biology in the Department of Microbiology, Immunology, and Molecular Genetics and is a member of the Molecular Biology Institute at the University of California, Los Angeles. Dr. Berk is also a fellow of the American Academy of Arts and Sciences. He is one of the discoverers of RNA splicing and of mechanisms for gene control in viruses. His laboratory studies the molecular interactions that regulate transcription initiation in mammalian cells, focusing in particular on adenovirus regulatory proteins. He teaches an advanced undergraduate course in cell biology of the nucleus and a graduate course in the biochemistry of gene expression.

Chris A. Kaiser

CHRIS A. KAISER is the Amgen Inc. Professor in the Department of Biology at the Massachusetts Institute of Technology. He is also a former Department Head and former Provost at MIT. His laboratory uses genetic and cell biological methods to understand how newly synthesized membrane and secretory proteins are folded and stored in the compartments of the secretory pathway. Dr. Kaiser is recognized as a top educator at MIT, where he has taught genetics to undergraduate and graduate students for many years.

Monty Krieger

MONTY KRIEGER is the Whitehead Professor in the Department of Biology at the Massachusetts Institute of Technology and a Senior Associate Member of the Broad Institute of MIT and Harvard. Dr. Krieger is also a member of the National Academy of Sciences. For his innovative teaching of undergraduate biology and human physiology as well as graduate cell biology courses, he has received numerous awards. His laboratory has made contributions to our understanding of membrane trafficking through the Golgi apparatus and has cloned and characterized receptor proteins important for pathogen recognition and the movement of cholesterol into and out of cells, including the HDL receptor.

Anthony Bretscher

ANTHONY BRETSCHER is Professor of Cell Biology at Cornell University and a member of the Weill Institute for Cell and Molecular Biology. His laboratory is well known for identifying and characterizing new components of the actin cytoskeleton and elucidating their biological functions in relation to cell polarity and membrane traffic. For this work, his laboratory exploits biochemical, genetic, and cell biological approaches in two model systems, vertebrate epithelial cells and the budding yeast. He is a fellow of the American Academy of Arts and Sciences. Dr. Bretscher teaches cell biology to undergraduates at Cornell University.

Hidde Ploegh

HIDDE PLOEGH is a senior investigator in the Program of Cellular and Molecular Medicine at Boston Children’s Hospital, where he studies the biochemistry of the immune system. A Member of the National Academy of Science and the American Academy of Arts and Sciences, he is one of the world’s leading researchers in the molecular understanding of immune system cells and the mechanisms by which viruses evade detection by the immune system. Prior to his current position he was a professor at the Massachusetts Institute of Technology and Harvard Medical School, where he taught immunology and cell biology.

Kelsey C. Martin

KELSEY C. MARTIN is Professor of Biological Chemistry and Psychiatry and Dean of the David Geffen School of Medicine at the University of California, Los Angeles. She is the former Chair of the Biological Chemistry Department. Her laboratory studies the ways in which experience changes connections between neurons in the brain to store long-term memories—a process known as synaptic plasticity. She has made important contributions to elucidating the molecular and cell biological mechanisms that underlie this process. Dr. Martin teaches basic principles of neuroscience to undergraduates, graduate students, dental students, and medical students.

Michael Yaffe

MICHAEL B. YAFFE is the David H. Koch Professor of Science in the Departments of Biology and Biological Engineering at the Massachusetts Institute of Technology and a Senior Associate Member of the Broad Institute of MIT and Harvard. He is also the Academic Editor-in-Chief of the journal Science Signaling. His laboratory studies the cellular response to stress and injury, and is well known for the discovery and characterization of modular protein domains and protein kinases that form molecular signaling circuits. Dr. Yaffe teaches undergraduate biochemistry and graduate cell biology courses, for which he has received numerous awards. He also instructs medical students and residents in the intensive care unit at the Beth Israel Deaconess Medical Center, where he is an attending physician.

Angelika Amon

ANGELIKA AMON is Professor of Biology at the Massachusetts Institute of Technology, a member of the Koch Institute for Integrative Cancer Research, and Investigator at the Howard Hughes Medical Institute. She is also a member of the National Academy of Sciences. Her laboratory studies the molecular mechanisms that govern chromosome segregation during mitosis and meiosis and the consequences—aneuploidy—when these mechanisms fail during normal cell proliferation and cancer development. Dr. Amon teaches undergraduate and graduate courses in cell biology and genetics.

Molecules, Cells, and Model Organisms
Chemical Foundations
Protein Structure and Function
Culturing and Visualizing Cells
Fundamental Molecular Genetic Mechanisms
Molecular Genetic Techniques
Genes and Genomics
Transcriptional Control of Gene Expression
Post-Transcriptional Gene Control
Biomembrane Structure
Transmembrane Transport of Ions and Small Molecules
Cellular Energetics
Moving Proteins into Membranes and Organelles
Vesicular Traffic, Secretion, and Endocytosis
Cell Signaling I
Growth Factor and Cytokine Signaling
Cell Organization and Movement I
Cell Organization and Movement II
The Eukaryotic Cell Cycle
Integrating Cells into Tissues
Responding to the Cellular Environment
Stem Cells, Cell Asymmetry, and Cell Death
Nerve Cells
Immunology
Cancer

Product Updates

Now Supported in Achieve
Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding biology content provides an unrivaled learning experience.

Features of Achieve include:

A design guided by learning science research. Co-designed through extensive collaboration and testing by both students and faculty including two levels of Institutional Review Board approval for every study of Achieve
A learning path of powerful content including pre-class, in-class, and post-class activities and assessments.
A detailed gradebook with insights for just-in-time teaching and reporting on student achievement by learning objective.
Easy integration and gradebook sync with iClicker classroom engagement solutions.
Simple integration with your campus LMS and availability through Inclusive Access programs.

New media and assessment features in Achieve include:

New Smart Biology Animations provide cutting-edge 3D tools for students to help them understand cell biology at a structural level. Based on data from the World Wide Protein Databank, these animations provide students with highly accurate visualizations of structures and processes. Twenty six of these animations are included in Achieve and include associated assessments so that they can be assigned and automatically graded.
Eight New In-class activities, along with revised classroom response questions provide support for an active and inclusive classroom.
LearningCurve adaptive quizzes provide formative assessments to help students prepare before class.
Case Studies and Analyze the Data Problems focus on real world applications.
Chapter Concept Quizzes provide easy to assign and automatically graded assessments.

Updates to the text include:

Updated content throughout the text highlight new methodologies and latest research discoveries.
New Chapter 21: Responding to the Cellular Environment
reflects recent developments in cell signaling and expanded coverage to emphasize new research developments.
New co-author Michael Yaffe from MIT is a cancer specialist on the frontlines of COVID19 treatment and research. https://ki.mit.edu/people/faculty/yaffe

Authors

Harvey Lodish

HARVEY LODISH is Professor of Biology and Professor of Biological Engineering at the Massachusetts Institute of Technology and a Founding Member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell-membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and TGF–β receptors. His laboratory also studies long noncoding RNAs and microRNAs that regulate the development and function of hematopoietic cells and adipocytes. Dr. Lodish teaches undergraduate and graduate courses in cell biology and biotechnology.

Arnold Berk

ARNOLD BERK holds the UCLA Presidential Chair in Molecular Cell Biology in the Department of Microbiology, Immunology, and Molecular Genetics and is a member of the Molecular Biology Institute at the University of California, Los Angeles. Dr. Berk is also a fellow of the American Academy of Arts and Sciences. He is one of the discoverers of RNA splicing and of mechanisms for gene control in viruses. His laboratory studies the molecular interactions that regulate transcription initiation in mammalian cells, focusing in particular on adenovirus regulatory proteins. He teaches an advanced undergraduate course in cell biology of the nucleus and a graduate course in the biochemistry of gene expression.

Chris A. Kaiser

CHRIS A. KAISER is the Amgen Inc. Professor in the Department of Biology at the Massachusetts Institute of Technology. He is also a former Department Head and former Provost at MIT. His laboratory uses genetic and cell biological methods to understand how newly synthesized membrane and secretory proteins are folded and stored in the compartments of the secretory pathway. Dr. Kaiser is recognized as a top educator at MIT, where he has taught genetics to undergraduate and graduate students for many years.

Monty Krieger

MONTY KRIEGER is the Whitehead Professor in the Department of Biology at the Massachusetts Institute of Technology and a Senior Associate Member of the Broad Institute of MIT and Harvard. Dr. Krieger is also a member of the National Academy of Sciences. For his innovative teaching of undergraduate biology and human physiology as well as graduate cell biology courses, he has received numerous awards. His laboratory has made contributions to our understanding of membrane trafficking through the Golgi apparatus and has cloned and characterized receptor proteins important for pathogen recognition and the movement of cholesterol into and out of cells, including the HDL receptor.

Anthony Bretscher

ANTHONY BRETSCHER is Professor of Cell Biology at Cornell University and a member of the Weill Institute for Cell and Molecular Biology. His laboratory is well known for identifying and characterizing new components of the actin cytoskeleton and elucidating their biological functions in relation to cell polarity and membrane traffic. For this work, his laboratory exploits biochemical, genetic, and cell biological approaches in two model systems, vertebrate epithelial cells and the budding yeast. He is a fellow of the American Academy of Arts and Sciences. Dr. Bretscher teaches cell biology to undergraduates at Cornell University.

Hidde Ploegh

HIDDE PLOEGH is a senior investigator in the Program of Cellular and Molecular Medicine at Boston Children’s Hospital, where he studies the biochemistry of the immune system. A Member of the National Academy of Science and the American Academy of Arts and Sciences, he is one of the world’s leading researchers in the molecular understanding of immune system cells and the mechanisms by which viruses evade detection by the immune system. Prior to his current position he was a professor at the Massachusetts Institute of Technology and Harvard Medical School, where he taught immunology and cell biology.

Kelsey C. Martin

KELSEY C. MARTIN is Professor of Biological Chemistry and Psychiatry and Dean of the David Geffen School of Medicine at the University of California, Los Angeles. She is the former Chair of the Biological Chemistry Department. Her laboratory studies the ways in which experience changes connections between neurons in the brain to store long-term memories—a process known as synaptic plasticity. She has made important contributions to elucidating the molecular and cell biological mechanisms that underlie this process. Dr. Martin teaches basic principles of neuroscience to undergraduates, graduate students, dental students, and medical students.

Michael Yaffe

MICHAEL B. YAFFE is the David H. Koch Professor of Science in the Departments of Biology and Biological Engineering at the Massachusetts Institute of Technology and a Senior Associate Member of the Broad Institute of MIT and Harvard. He is also the Academic Editor-in-Chief of the journal Science Signaling. His laboratory studies the cellular response to stress and injury, and is well known for the discovery and characterization of modular protein domains and protein kinases that form molecular signaling circuits. Dr. Yaffe teaches undergraduate biochemistry and graduate cell biology courses, for which he has received numerous awards. He also instructs medical students and residents in the intensive care unit at the Beth Israel Deaconess Medical Center, where he is an attending physician.

Angelika Amon

ANGELIKA AMON is Professor of Biology at the Massachusetts Institute of Technology, a member of the Koch Institute for Integrative Cancer Research, and Investigator at the Howard Hughes Medical Institute. She is also a member of the National Academy of Sciences. Her laboratory studies the molecular mechanisms that govern chromosome segregation during mitosis and meiosis and the consequences—aneuploidy—when these mechanisms fail during normal cell proliferation and cancer development. Dr. Amon teaches undergraduate and graduate courses in cell biology and genetics.

Molecules, Cells, and Model Organisms
Chemical Foundations
Protein Structure and Function
Culturing and Visualizing Cells
Fundamental Molecular Genetic Mechanisms
Molecular Genetic Techniques
Genes and Genomics
Transcriptional Control of Gene Expression
Post-Transcriptional Gene Control
Biomembrane Structure
Transmembrane Transport of Ions and Small Molecules
Cellular Energetics
Moving Proteins into Membranes and Organelles
Vesicular Traffic, Secretion, and Endocytosis
Cell Signaling I
Growth Factor and Cytokine Signaling
Cell Organization and Movement I
Cell Organization and Movement II
The Eukaryotic Cell Cycle
Integrating Cells into Tissues
Responding to the Cellular Environment
Stem Cells, Cell Asymmetry, and Cell Death
Nerve Cells
Immunology
Cancer

Product Updates

Features of Achieve include:

A design guided by learning science research. Co-designed through extensive collaboration and testing by both students and faculty including two levels of Institutional Review Board approval for every study of Achieve
A learning path of powerful content including pre-class, in-class, and post-class activities and assessments.
A detailed gradebook with insights for just-in-time teaching and reporting on student achievement by learning objective.
Easy integration and gradebook sync with iClicker classroom engagement solutions.
Simple integration with your campus LMS and availability through Inclusive Access programs.

New media and assessment features in Achieve include:

New Smart Biology Animations provide cutting-edge 3D tools for students to help them understand cell biology at a structural level. Based on data from the World Wide Protein Databank, these animations provide students with highly accurate visualizations of structures and processes. Twenty six of these animations are included in Achieve and include associated assessments so that they can be assigned and automatically graded.
Eight New In-class activities, along with revised classroom response questions provide support for an active and inclusive classroom.
LearningCurve adaptive quizzes provide formative assessments to help students prepare before class.
Case Studies and Analyze the Data Problems focus on real world applications.
Chapter Concept Quizzes provide easy to assign and automatically graded assessments.

Updates to the text include:

Updated content throughout the text highlight new methodologies and latest research discoveries.
New Chapter 21: Responding to the Cellular Environment
reflects recent developments in cell signaling and expanded coverage to emphasize new research developments.
New co-author Michael Yaffe from MIT is a cancer specialist on the frontlines of COVID19 treatment and research. https://ki.mit.edu/people/faculty/yaffe

GO DIGITAL WITH ACHIEVE
The authoritative Cell Biology resource, now available with Achieve

Available for the first time with Macmillans new online learning tool, Achieve, Molecular Cell Biology remains the most authoritative and cutting-edge resource available for the cell biology course. The author team, consisting of world-class researchers and teachers, incorporates medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. The emphasis on experimental techniques that drive advances in biomedical sciences teaches students the skills they need for their careers.

Achieve, Macmillan’s new online learning platform, supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. Featuring new digital resources to engage students and help them to master cell biology concepts, the pairing of a powerful new platform with outstanding biology content provides an unrivaled learning experience.

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