Cover: Biochemistry, 10th Edition by Jeremy Berg; Gregory Gatto Jr.; Justin Hines; John L. Tymoczko; Lubert Stryer

Biochemistry

Tenth Edition  ©2023 Jeremy Berg; Gregory Gatto Jr.; Justin Hines; John L. Tymoczko; Lubert Stryer Formats: Achieve, Achieve Essentials, E-book, Print

Authors

  • Headshot of Jeremy M. Berg

    Jeremy M. Berg

    Jeremy M. Berg received his B.S. and M.S. degrees in Chemistry from Stanford University (where he did research with Keith Hodgson and Lubert Stryer) and his PhD in Chemistry from Harvard with Richard Holm. He then completed a postdoctoral fellowship with Carl Pabo in Biophysics at Johns Hopkins University School of Medicine. He was an Assistant Professor in the Department of Chemistry at Johns Hopkins from 1986 to 1990. He then moved to Johns Hopkins University S­chool of Medicine as Professor and Director of the Department of Biophysics and Biophysical Chemistry, where he remained until 2003. He then became Director of the National Institute of General Medical Sciences at the National Institutes of Health. In 2011, he moved to the University of Pittsburgh, where he is now Professor of Computational and Systems Biology and Pittsburgh Foundation Chair and Director of the Institute for Personalized Medicine. He served as President of the American Society for Biochemistry and Molecular Biology from 2011 to 2013 and as Editor-in-Chief for Science magazine and the Science family of journals from 2016 to 2019. Dr. Berg has received numerous awards for his research, teaching, and public service. He is an elected member of the National Academy of Medicine and the American Academy of Arts and Sciences. He is coauthor, with Stephen J. Lippard, of the textbook Principles of Bioinorganic Chemistry. He greatly enjoys sharing his life with his wife, three grown children, and grandchildren.

  • Headshot of Gregory J. Gatto, Jr.

    Gregory J. Gatto, Jr.

    Gregory J. Gatto, Jr., received his A.B. degree in Chemistry from Princeton University, where he worked with Martin F. Semmelhack and was awarded the Everett S. Wallis Prize in Organic Chemistry. In 2003, he received his MD and PhD degrees from the Johns Hopkins University School of Medicine, where he studied the structural biology of peroxisomal targeting signal recognition with Dr. Berg and received the Michael A. Shanoff Young Investigator Research Award. He completed a postdoctoral fellowship in 2006 with Christopher T. Walsh at Harvard Medical School, where he studied the biosynthesis of the macrolide immunosuppressants. Dr. Gatto is currently a Scientific Director in the Novel Human Genetics Research Unit at GlaxoSmithKline. While he enjoys losing at board games, attempting but not completing crossword puzzles, and watching baseball games at every available opportunity, he treasures most the time he spends with his wife Megan and sons Timothy and Mark.

  • Headshot of Justin Hines

    Justin Hines

    Justin K. Hines is Professor of Chemistry at Lafayette College, where he teaches general chemistry and biochemistry courses and conducts education and NIH-funded laboratory research on protein misfolding with undergraduates. He received both his B.S. and PhD in Biochemistry from Iowa State University, where he studied the structure and regulation of the enzymes of central metabolism with Richard B. Honzatko and Herbert J. Fromm. He then completed a postdoctoral fellowship with Elizabeth A. Craig in Biochemistry at the University of Wisconsin–Madison. Professor Hines has won numerous awards for teaching and research, including being named a Cottrell Scholar by the Research Corporation for Science Advancement and a Henry-Dreyfus Teacher-Scholar by the Camille and Henry Dreyfus Foundation. He is also the author of the case-studies series for Macmillan’s three biochemistry textbooks. He enjoys running, hiking, games of any kind, and spending time with his wife and children.

  • Headshot of John L. Tymoczko

    John L. Tymoczko

    John L. Tymoczko was Towsley Professor of Biology Emeritus at Carleton College, where he taught from 1976 until his death in 2019. He taught a variety of courses, including Biochemistry, Biochemistry Laboratory, Oncogenes and the Molecular Biology of Cancer, and Exercise Biochemistry, and cotaught an introductory course, Energy Flow in Biological Systems. Professor Tymoczko received his B.A. from the University of Chicago in 1970 and his PhD in Biochemistry from the University of Chicago with Shutsung Liao at the Ben May Institute for Cancer Research. He then had a postdoctoral position with Hewson Swift of the Department of Biology at the University of Chicago. The focus of his research was on steroid receptors, ribonucleoprotein particles, and proteolytic processing enzymes.

  • Headshot of Lubert Stryer

    Lubert Stryer

    Lubert Stryer is Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, where he has been on the faculty since 1976. He received his MD from Harvard Medical School. Professor Stryer has received many awards for his research on the interplay of light and life, including the Eli Lilly Award for Fundamental Research in Biological Chemistry, the Distinguished Inventors Award of the Intellectual Property Owners’ Association, and election to the National Academy of Sciences and the American Philosophical Society. He was awarded the National Medal of Science in 2006. The publication of his first edition of Biochemistry in 1975 transformed the teaching of biochemistry.

Table of Contents

1  Biochemistry in Space and Time
2  Protein Composition and Structure
3  Binding and Molecular Recognition
4  Protein Methods
5  Enzymes: Core Concepts and Kinetics
6  Enzyme Catalytic Strategies
7  Enzyme Regulatory Strategies
8  DNA, RNA, and the Flow of Genetic Information
9  Nucleic Acid Methods
10  Exploring Evolution and Bioinformatics
11  Carbohydrates and Glycoproteins
12  Lipids and Biological Membranes
13  Membrane Channels and Pumps
14  Signal-Transduction Pathways
15  Metabolism: Basic Concepts and Themes
16  Glycolysis and Gluconeogenesis
17  Pyruvate Dehydrogenase and the Citric Acid Cycle
18  Oxidative Phosphorylation
19  Phototrophy and the Light Reactions of Photosynthesis
20  The Calvin–Benson Cycle and the Pentose Phosphate Pathway
21  Glycogen Metabolism
22  Fatty Acid and Triacylglycerol Metabolism
23  Protein Turnover and Amino Acid Catabolism
24  Integration of Energy Metabolism
25  Biosynthesis of Amino Acids
26  Nucleotide Biosynthesis
27  Biosynthesis of Membrane Lipids and Steroids
28  DNA Replication, Repair, and Recombination
29  RNA Functions, Biosynthesis, and Processing
30  Protein Biosynthesis
31  Control of Gene Expression
32  Principles of Drug Discovery and Development

Product Updates

Chapter content has been thoughtfully revised around the themes of evolutionary perspective, clinical applications and physiological relevance, biotechnological and industrial applications, and NEW! the importance of time and time scales. For example:

  • NEW! Chapter 3 focuses on molecular recognition
  • Updated and new discussions with clinical and physiological applications, such as anticoagulant medicines (chapter 7), metabolism and cancer (chapter 24), and drug discovery (chapter 32)
  • Updated and new illustrations
  • NEW! Problem-solving techniques and practice throughout the text and online, such as:
  • NEW! Self-check questions and worked examples
  • NEW in Achieve! Every end-of-chapter now assignable online with autograding, answer-specific feedback, and worked solutions
  • NEW in Achieve! Skills You Need Activities for each chapter reinforce skills and concepts from prerequisite courses
  • NEW in Achieve! iClicker activities and free integration with iClicker
  • NEW in Achieve!  In-Class Activities for Problem Solving with Instructor Activity Guides and Student Worksheets
  • NEW! Scientist Profiles illustrating the wide range of backgrounds, training, and careers that lead to many important contributions in biochemistry.

Authors

  • Headshot of Jeremy M. Berg

    Jeremy M. Berg

    Jeremy M. Berg received his B.S. and M.S. degrees in Chemistry from Stanford University (where he did research with Keith Hodgson and Lubert Stryer) and his PhD in Chemistry from Harvard with Richard Holm. He then completed a postdoctoral fellowship with Carl Pabo in Biophysics at Johns Hopkins University School of Medicine. He was an Assistant Professor in the Department of Chemistry at Johns Hopkins from 1986 to 1990. He then moved to Johns Hopkins University S­chool of Medicine as Professor and Director of the Department of Biophysics and Biophysical Chemistry, where he remained until 2003. He then became Director of the National Institute of General Medical Sciences at the National Institutes of Health. In 2011, he moved to the University of Pittsburgh, where he is now Professor of Computational and Systems Biology and Pittsburgh Foundation Chair and Director of the Institute for Personalized Medicine. He served as President of the American Society for Biochemistry and Molecular Biology from 2011 to 2013 and as Editor-in-Chief for Science magazine and the Science family of journals from 2016 to 2019. Dr. Berg has received numerous awards for his research, teaching, and public service. He is an elected member of the National Academy of Medicine and the American Academy of Arts and Sciences. He is coauthor, with Stephen J. Lippard, of the textbook Principles of Bioinorganic Chemistry. He greatly enjoys sharing his life with his wife, three grown children, and grandchildren.

  • Headshot of Gregory J. Gatto, Jr.

    Gregory J. Gatto, Jr.

    Gregory J. Gatto, Jr., received his A.B. degree in Chemistry from Princeton University, where he worked with Martin F. Semmelhack and was awarded the Everett S. Wallis Prize in Organic Chemistry. In 2003, he received his MD and PhD degrees from the Johns Hopkins University School of Medicine, where he studied the structural biology of peroxisomal targeting signal recognition with Dr. Berg and received the Michael A. Shanoff Young Investigator Research Award. He completed a postdoctoral fellowship in 2006 with Christopher T. Walsh at Harvard Medical School, where he studied the biosynthesis of the macrolide immunosuppressants. Dr. Gatto is currently a Scientific Director in the Novel Human Genetics Research Unit at GlaxoSmithKline. While he enjoys losing at board games, attempting but not completing crossword puzzles, and watching baseball games at every available opportunity, he treasures most the time he spends with his wife Megan and sons Timothy and Mark.

  • Headshot of Justin Hines

    Justin Hines

    Justin K. Hines is Professor of Chemistry at Lafayette College, where he teaches general chemistry and biochemistry courses and conducts education and NIH-funded laboratory research on protein misfolding with undergraduates. He received both his B.S. and PhD in Biochemistry from Iowa State University, where he studied the structure and regulation of the enzymes of central metabolism with Richard B. Honzatko and Herbert J. Fromm. He then completed a postdoctoral fellowship with Elizabeth A. Craig in Biochemistry at the University of Wisconsin–Madison. Professor Hines has won numerous awards for teaching and research, including being named a Cottrell Scholar by the Research Corporation for Science Advancement and a Henry-Dreyfus Teacher-Scholar by the Camille and Henry Dreyfus Foundation. He is also the author of the case-studies series for Macmillan’s three biochemistry textbooks. He enjoys running, hiking, games of any kind, and spending time with his wife and children.

  • Headshot of John L. Tymoczko

    John L. Tymoczko

    John L. Tymoczko was Towsley Professor of Biology Emeritus at Carleton College, where he taught from 1976 until his death in 2019. He taught a variety of courses, including Biochemistry, Biochemistry Laboratory, Oncogenes and the Molecular Biology of Cancer, and Exercise Biochemistry, and cotaught an introductory course, Energy Flow in Biological Systems. Professor Tymoczko received his B.A. from the University of Chicago in 1970 and his PhD in Biochemistry from the University of Chicago with Shutsung Liao at the Ben May Institute for Cancer Research. He then had a postdoctoral position with Hewson Swift of the Department of Biology at the University of Chicago. The focus of his research was on steroid receptors, ribonucleoprotein particles, and proteolytic processing enzymes.

  • Headshot of Lubert Stryer

    Lubert Stryer

    Lubert Stryer is Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, where he has been on the faculty since 1976. He received his MD from Harvard Medical School. Professor Stryer has received many awards for his research on the interplay of light and life, including the Eli Lilly Award for Fundamental Research in Biological Chemistry, the Distinguished Inventors Award of the Intellectual Property Owners’ Association, and election to the National Academy of Sciences and the American Philosophical Society. He was awarded the National Medal of Science in 2006. The publication of his first edition of Biochemistry in 1975 transformed the teaching of biochemistry.

Table of Contents

1  Biochemistry in Space and Time
2  Protein Composition and Structure
3  Binding and Molecular Recognition
4  Protein Methods
5  Enzymes: Core Concepts and Kinetics
6  Enzyme Catalytic Strategies
7  Enzyme Regulatory Strategies
8  DNA, RNA, and the Flow of Genetic Information
9  Nucleic Acid Methods
10  Exploring Evolution and Bioinformatics
11  Carbohydrates and Glycoproteins
12  Lipids and Biological Membranes
13  Membrane Channels and Pumps
14  Signal-Transduction Pathways
15  Metabolism: Basic Concepts and Themes
16  Glycolysis and Gluconeogenesis
17  Pyruvate Dehydrogenase and the Citric Acid Cycle
18  Oxidative Phosphorylation
19  Phototrophy and the Light Reactions of Photosynthesis
20  The Calvin–Benson Cycle and the Pentose Phosphate Pathway
21  Glycogen Metabolism
22  Fatty Acid and Triacylglycerol Metabolism
23  Protein Turnover and Amino Acid Catabolism
24  Integration of Energy Metabolism
25  Biosynthesis of Amino Acids
26  Nucleotide Biosynthesis
27  Biosynthesis of Membrane Lipids and Steroids
28  DNA Replication, Repair, and Recombination
29  RNA Functions, Biosynthesis, and Processing
30  Protein Biosynthesis
31  Control of Gene Expression
32  Principles of Drug Discovery and Development

Product Updates

Chapter content has been thoughtfully revised around the themes of evolutionary perspective, clinical applications and physiological relevance, biotechnological and industrial applications, and NEW! the importance of time and time scales. For example:

  • NEW! Chapter 3 focuses on molecular recognition
  • Updated and new discussions with clinical and physiological applications, such as anticoagulant medicines (chapter 7), metabolism and cancer (chapter 24), and drug discovery (chapter 32)
  • Updated and new illustrations
  • NEW! Problem-solving techniques and practice throughout the text and online, such as:
  • NEW! Self-check questions and worked examples
  • NEW in Achieve! Every end-of-chapter now assignable online with autograding, answer-specific feedback, and worked solutions
  • NEW in Achieve! Skills You Need Activities for each chapter reinforce skills and concepts from prerequisite courses
  • NEW in Achieve! iClicker activities and free integration with iClicker
  • NEW in Achieve!  In-Class Activities for Problem Solving with Instructor Activity Guides and Student Worksheets
  • NEW! Scientist Profiles illustrating the wide range of backgrounds, training, and careers that lead to many important contributions in biochemistry.

Biochemistry 10e with Achieve builds on over four decades of exceptional writing, clear graphics, coverage of the latest research technique, and its signature emphasis on physiological and medical relevance with new emphasis on the importance of diversity and team work and a focus on problem-solving techniques and skills.

With a new and updated suite of online resources, including hundreds of end-of-chapter problems with answer-specific feedback, activities for in-class and out-of-class, and an emphasis on visualization, Biochemistry with Achieve sets a new standard for biochemistry programs!

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Jeremy Berg; Gregory Gatto Jr.; Justin Hines; John L. Tymoczko; Lubert Stryer | Tenth Edition | ©2023 | ISBN:9781319418083

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