Cover: Biology: How Life Works, 4th Edition by James Morris; Daniel Hartl; Andrew Knoll; Robert Lue; Melissa Michael; Andrew Berry; Andrew Biewener; Brian Farrell; N. Michele Holbrook; Jessica Liu; Jean Heitz; Mark Hens; Elena Lozovsky; John Merrill; Randall Phillis; Debra Pires

Biology: How Life Works

Fourth Edition  ©2023 James Morris; Daniel Hartl; Andrew Knoll; Robert Lue; Melissa Michael; Andrew Berry; Andrew Biewener; Brian Farrell; N. Michele Holbrook; Jessica Liu; Jean Heitz; Mark Hens; Elena Lozovsky; John Merrill; Randall Phillis; Debra Pires Formats: Achieve, E-book, Print

Authors

  • Headshot of James Morris

    James Morris

    James Morris is Professor of Biology at Brandeis University. He teaches a wide variety of courses for majors and non-majors, including introductory biology, evolution, genetics and genomics, epigenetics, comparative vertebrate anatomy, and a first-year seminar on Darwin’s On the Origin of Species. He is the recipient of numerous teaching awards from Brandeis and Harvard. His research focuses on epigenetics. He currently pursues this research with undergraduates to give them the opportunity to do genuine, laboratory-based research. Dr. Morris received a PhD in genetics from Harvard University and an MD from Harvard Medical School. He was a Junior Fellow in the Society of Fellows at Harvard University and a National Academies Education Fellow and Mentor in the Life Sciences. He is also a reader for the AP® Biology exam and an author of Biology for the AP® Course.


  • Headshot of Daniel Hartl

    Daniel Hartl

    Daniel L. Hartl is Higgins Professor of Biology in the Department of Organismic and Evolutionary Biology at Harvard University and Professor of Immunology and Infectious Diseases at the Harvard T. H. Chan School of Public Health. He has taught highly popular courses in genetics and evolution at both the introductory and advanced levels. His lab studies molecular evolutionary genetics and population genetics and genomics. Dr. Hartl has been awarded the Thomas Hunt Morgan Medal from the Genetics Society of America, the Samuel Weiner Outstanding Scholar Award, and the Gold Medal of the Stazione Zoologica Anton Dohrn in Naples, Italy. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. He has served as President of the Genetics Society of America and President of the Society for Molecular Biology and Evolution. Dr. Hartl’s PhD is from the University of Wisconsin, and he did postdoctoral studies at the University of California, Berkeley. Before joining the Harvard faculty, he served on the faculties of the University of Minnesota, Purdue University, and Washington University Medical School. In addition to publishing more than 450 scientific articles, Dr. Hartl has authored or coauthored 35 books.


  • Headshot of Andrew Knoll

    Andrew Knoll

    Andrew H. Knoll is Fisher Research Professor of Natural History in the Department of Organismic and Evolutionary Biology at Harvard University. He is also Professor of Earth and Planetary Sciences and taught introductory courses for many years in both departments. Dr. Knoll’s research focuses on the early evolution of life, Earth dynamic environmental history, and the interconnections between the two. He has also worked extensively on the early evolution of animals, mass extinction, and plant evolution, and he served on the science team for NASA’s MER mission to Mars. Dr. Knoll received the Phi Beta Kappa Book Award in Science for Life on a Young Planet. In 2018, he was awarded the International Prize for Biology and in 2022, he received the prestigious Crafoord Prize in Geosciences for his research on Earth’s early history. He is a member of the National Academy of Sciences and a foreign member of the Royal Society of London. Dr. Knoll received his PhD from Harvard University and taught at Oberlin College before returning to Harvard.


  • Headshot of Robert Lue

    Robert Lue

    Robert Lue was Professor of Molecular and Cellular Biology at Harvard University and the Richard L. Menschel Faculty Director of the Derek Bok Center for Teaching and Learning. Dr. Lue had a longstanding commitment to interdisciplinary teaching and research and chaired the faculty committee that developed the first integrated science foundation in the country to serve science majors as well as pre-medical students. The founding director of Life Sciences Education at Harvard, Dr. Lue led a complete redesign of the introductory curriculum, redefining how the university can more effectively foster new generations of scientists as well as science-literate citizens. Dr. Lue also developed award-winning multimedia, including the animation The Inner Life of the Cell. He coauthored undergraduate biology textbooks and chaired education conferences on college biology for the National Academies and the National Science Foundation and on diversity in science for the Howard Hughes Medical Institute and the National Institutes of Health. In 2012, Dr. Lue’s extensive work on using technology to enhance learning took a new direction when he became faculty director of university-wide online education initiative HarvardX. Dr. Lue earned his PhD from Harvard University.


  • Headshot of Melissa Michael

    Melissa Michael

    Melissa Michael is Associate Director for Curriculum and Instruction in the School of Molecular and Cellular Biology at the University of Illinois at Urbana-Champaign. Associate Director Michael primarily focuses on the continuing development of the School’s undergraduate curricula. Her research focuses on the ways in which formative assessment strategies affect student learning outcomes in large-enrollment courses. She leads a new initiative to bring inclusive teaching practices to STEM courses. A member of the leadership for Mobile Summer Institutes for Scientific Teaching, she is now serving as an officer on the inaugural Executive Committee for the National Institute on Scientific Teaching.


  • Headshot of Andrew Berry

    Andrew Berry

    Andrew Berry is Lecturer in the Department of Organismic and Evolutionary Biology and an undergraduate advisor in the Life Sciences at Harvard University. With research interests in evolutionary biology and history of science, he teaches courses that either focus on one of the areas or combine the two. He has written two books: Infinite Tropics, a collection of the writings of Alfred Russel Wallace, and, with James D. Watson, DNA: The Secret of Life, which is part history, part exploration of the controversies surrounding DNA-based technologies.


  • Headshot of Andrew Biewener

    Andrew Biewener

    Andrew Biewener is the Charles P. Lyman Professor of Biology in the Department of Organismic and Evolutionary Biology at Harvard University and Director of the Concord Field Station. He teaches both introductory and advanced courses in anatomy, physiology, and biomechanics. His research focuses on the comparative biomechanics and neuromuscular control of mammalian and avian locomotion, with relevance to biorobotics. He served as Deputy Editor-in-Chief for the Journal of Experimental Biology and has also served as President of the American Society of Biomechanics.


  • Headshot of Brian Farrell

    Brian Farrell

    Brian D. Farrell is the Monique and Philip Lehner Professor for the Study of Latin America, a faculty member in the Department of Organismic and Evolutionary Biology, and Curator in Entomology at the Museum of Comparative Zoology at Harvard University. He is an authority on coevolution between insects and plants and a specialist on the biology of beetles. He teaches the large introductory course in organismic biology and a Freshmen Seminar in acoustic biology, and is interested in the impact of biophilia on human health. In 2011–2012, he was a Fulbright Scholar to the Universidad Autónoma de Santo Domingo in the Dominican Republic. Dr. Farrell received a BA in Zoology and Botany from the University of Vermont and MS and PhD from the University of Maryland.


  • Headshot of N. Michele Holbrook

    N. Michele Holbrook

    N. Michele Holbrook is Charles Bullard Professor of Forestry in the Department of Organismic and Evolutionary Biology at Harvard University, Head Tutor in Harvard’s undergraduate program in Environmental Policy and Public Policy, and Director of the Harvard Forest. She teaches introductory and advanced courses on plant biology and plant physiology, as well as courses on trees, forests, and climate change. Her research focuses on the physics and physiology of vascular transport in plants. Dr. Holbrook received her PhD from Stanford University.


  • Headshot of Jessica Liu

    Jessica Liu

    Jessica C. Liu is a preceptor in the Department of Molecular and Cellular Biology at Harvard University with a focus on teaching, pedagogy, and curriculum development. Dr. Liu received her BS from The University of Texas at Austin and her PhD in biochemistry from Harvard in 2015. She has been teaching intermediate undergraduate courses along with Robert Lue and Alain Viel since 2016 and is the recipient of multiple teaching awards from Harvard. She also serves as a member of her department’s Board of Tutors in Biochemical Sciences to provide intellectual support and mentorship to undergraduate students.


  • Headshot of Jean Heitz

    Jean Heitz

    Jean Heitz was Distinguished Faculty Associate at the University of Wisconsin – Madison, WI. She worked with the two-semester introductory sequence for biological sciences majors for over 40 years. Her primary roles included developing both interactive recitation activities designed to uncover and modify misconceptions in biology and open-ended investigative labs designed to give students a more authentic experience with science. The lab experience engaged all second-semester students in independent research, either mentored research or a library-based meta-analysis of an open question in the literature. She was also the advisor to the Peer Learning Association and was actively involved in TA training. She taught a graduate course in Teaching College Biology, presented active-learning workshops at a number of national and international meetings, and published a variety of lab modules, workbooks, and articles on biology education.


  • Headshot of Mark Hens

    Mark Hens

    Mark Hens is Associate Professor of Biology at the University of North Carolina Greensboro, where he has taught introductory biology since 1996. He is a National Academies Education Mentor in the Life Sciences and is the director of his department’s Introductory Biology Program. In this role, he guided the development of a comprehensive set of assessable student learning outcomes for the two-semester introductory biology course required of all science majors at UNCG. In various leadership roles in general education, both on his campus and statewide, he was instrumental in crafting a common set of assessable student learning outcomes for all natural science courses for which students receive general education credit on the 16 campuses of the University of North Carolina system.


  • Headshot of Elena Lozovsky

    Elena Lozovsky

    Elena Lozovsky is Principal Staff Scientist in the Department of Organismic and Evolutionary Biology at Harvard University. She received her PhD in genetics from Moscow State University in Russia and before joining Harvard carried out research at the Institute of Molecular Biology in Moscow, Cornell University, and Washington University School of Medicine in St. Louis. Her research has focused on transposable elements and genome evolution in eukaryotes and on the evolution of drug resistance in malaria parasites. She has also had extensive experience in teaching genetics and evolution.


  • Headshot of John Merrill

    John Merrill

    John Merrill is Faculty Emeritus in the College of Osteopathic Medicine at Michigan State University. He is former Director of the Biological Sciences Program which administers the core biology curriculum for all MSU science majors. He began his career studying the physiological ecology of marine algae but gradually shifted his focus to research on how undergraduate students learn biology and how to assess that learning. This work culminated in his leading “Beyond Multiple Choice” (beyondmultiplechoice.org) - a large, multi-institutional, NSF-funded project that developed an artificial intelligence (AI) system for computer-automated scoring of open-response assessment items.


  • Headshot of Randall Phillis

    Randall Phillis

    Randall Phillis is Associate Professor of Biology at the University of Massachusetts Amherst. He has taught in the majors introductory biology course at this institution for 27 years and is a National Academies Education Mentor in the Life Sciences. With help from the Pew Center for Academic Transformation (1999), he has been instrumental in transforming the introductory biology course to an active learning format that makes use of classroom communication systems. He also directed an NSF-funded project to design model-based reasoning assessment tools for use in class and on exams. These tools are being designed to develop and evaluate student scientific reasoning skills, with a focus on topics in introductory biology. He is currently a core faculty leader in an HHMI Inclusive Excellence grant with a focus on how CUREs in the first year can improve inclusion and success of all students in life science education.


  • Headshot of Debra Pires

    Debra Pires

    Debra Pires is an Academic Administrator and Vice Chair for the Department of Life Sciences Core Education at the University of California, Los Angeles. She has been teaching the majors introductory biology courses for 16 years. She is also the Instructional Consultant for the Center for Education Innovation & Learning in the Sciences (CEILS), and a certified trainer for the Mobile Summer Institutes. Many of her efforts are focused on curricular redesign of introductory biology courses. Through her work with CEILS and the MoSIs, she coordinates faculty development workshops that facilitate pedagogical changes associated with curricular developments. Her current research focuses on the impact of the experience of active learning pedagogies in lower-division courses on student performance and concept retention in upper-division courses.

Table of Contents

Watch Jim Morris explain the rationale behind the table of contents:
Video Part 1
Video Part 2

Part 1 From Cells to Organisms
Chapter 1 Chemical, Cellular, and Evolutionary Foundations of Life

Case 1 Life’s Origin: Homeostasis, Information, and Energy

Chapter 2 Molecules of Life
Chapter 3 Cells, Membranes, and Homeostasis
Chapter 4 Nucleic Acids and Information Flow
Chapter 5 Protein Structure, Function, and Synthesis
Visual Synthesis 1 Gene Expression
Chapter 6 Making Life Work
Chapter 7 Cellular Respiration
Chapter 8 Photosynthesis
Visual Synthesis 2 Harnessing Energy

Case 2 Cancer: Cell Signaling, Form, and Division
 
Chapter 9 Cell Signaling
Chapter 10 Cell and Tissue Form
Chapter 11 DNA Replication and Cell Division
Visual Synthesis 3 Cellular Communities

Case 3 Your Personal Genome: Variation and Inheritance

Chapter 12 Genomes and Biotechnology 
Chapter 13 Mutation and Genetic Variation
Chapter 14 Meiosis and Mendelian Inheritance
Chapter 15 Sex Chromosomes, Linked Genes, and Organelle Inheritance
Chapter 16 Complex Traits
Chapter 17 Genetic and Epigenetic Regulation
Chapter 18 Genes and Development
Visual Synthesis 4 Genetic Variation and Inheritance
Chapter 19 Viruses
Visual Synthesis 5 Viruses

Case 4 Malaria: Coevolution of Humans and a Parasite

Chapter 20 Evolution
Chapter 21 Species and Speciation
Visual Synthesis 6 Speciation
Chapter 22 Phylogeny, Fossils, and the History of Life
Chapter 23 Human Origins and Evolution
Visual Synthesis 7 History of Earth and Life

Part 2 From Organisms to the Environment

Case 5 The Human Microbiome: Diversity Within

Chapter 24 Bacteria and Archaea
Chapter 25 Eukaryotic Origins and Diversity
Chapter 26 Being Multicellular

Case 6 Agriculture: Feeding a Growing Population

Chapter 27 Plant Form, Function, and Diversity
Chapter 28 Plant Reproduction
Chapter 29 Plant Physiology
Visual Synthesis 8 Angiosperms
Chapter 30 Plant Growth and Development
Chapter 31 Plant Defense
Chapter 32 Fungi

Case 7 Bio-Inspired Design: Using Nature to Solve Problems

Chapter 33 Animal Form, Function, and Evolutionary History
Chapter 34 Animal Diversity
Visual Synthesis 9 Diversity Through Time
Chapter 35 Animal Nervous Systems
Chapter 36 Animal Movement
Chapter 37 Animal Endocrine Systems
Chapter 38 Animal Respiratory and Cardiovascular Systems [12]
Chapter 39 Animal Metabolism, Nutrition, and Digestion
Chapter 40 Animal Renal Systems
Visual Synthesis 10 Homeostasis [13]
Chapter 41 Animal Reproduction and Development
Chapter 42 Animal Immune Systems [14]

Case 8 Climate Change: Coral Reefs at Risk as the World Warms 

Chapter 43 Animal Behavior and Behavioral Ecology
Chapter 44 Population Ecology
Chapter 45 Species Interactions and Communities
Visual Synthesis 11 Succession
Chapter 46 Ecosystem Ecology
Visual Synthesis 12 Flow of Matter and Energy Through Ecosystems
Chapter 47 Climate and Biomes
Chapter 48 Humans as a Planetary Force

Primers
Scientific Inquiry   
Phylogenetic Trees
Quantitative Reasoning   
Models
Probability and Statistics  
Water Chemistry and Movement
Data and Data Visualization

Product Updates

Spring 2024 Updates:

  • 2 new Podcasts and Reflection assignments for Case 6 Beronda Montgomery on how the environment influences plant growth and Sheila Colla on protecting native insect pollinators. How Life Works Podcasts feature the contributions of a diverse group of scientists doing current research related to each of the cases.
  • Primers are designed to help students develop the skills they need to be successful in their biology courses and beyond. The new AI primer will introduce students to AI concepts and ethics.
  • New in-class activities were added for Chapter 22 on the History of Life, to help give students a sense of time and scale and Chapters 20 and 47 on the Great Bear Rainforest and Kermode Bear fur coloration.
  • Improvements were made to in-class activities throughout the course.

Fourth Edition Updates (2023)

A new chapter and case focus on current issues:

  • A new chapter, Viruses (Chapter 19), brings together material and concepts that were integrated throughout in previous editions. This chapter focuses on the structure, function, evolution, and ecology of viruses.
  • A new case, Climate Change (Case 8), brings this issue to the forefront. We focus on climate change and its devastating effects on coral reefs in the case itself, and then revisit climate change in the ecology chapters that follow, culminating in a look at human impacts and reasons for hope.

A new organization connects concepts and brings out stories:

  • We moved the discussion of cell form earlier (Chapter 3) so that students have a solid introduction to cell structure before moving on to cell function in the next set of chapters.
  • We discuss DNA replication along with mitotic cell division (Chapter 11), as the two processes are linked in the cell cycle and are important for understanding cancer.
  • We describe meiotic cell division and Mendelian inheritance in a single chapter (Chapter 14), helping students make connections between chromosome movement and inheritance patterns.
  • We devote a single chapter (Chapter 12) to genomes and biotechnology. Genomics is a modern science, providing a framework for the genetics chapters, and the techniques are applied in experiments throughout this section.
  • We rewrote and reorganized the plant chapters, starting with plant form, function, and diversity (Chapter 27). These chapters address the question of how plants evolved to survive and thrive on land, including the challenges of uniting gametes and dispersing offspring without being able to move (Chapter 28), obtaining CO2 without drying out (Chapter 29), using growth to respond to the environment (Chapter 30), and protecting themselves from being eaten without being able to run away (Chapter 31).
  • We discuss plant diversity (Chapter 27) and animal diversity (Chapter 34) so students are familiar with major groups of organisms before a detailed treatment of their anatomy and physiology.

Diverse scientists foster a sense of belonging:

  • Figures, examples, and experiments highlight the contributions of scientists with a wide range of backgrounds and experiences.
  • Careful attention was paid to the language, photos and pronouns used to be as inclusive as possible
  • A new set of podcasts feature the contributions of a diverse group of scientists doing current research related to each of the cases.

New activities and assessments support all students:

  • Goal Setting and Reflection Surveys help students learn how their expectations and behaviors contribute to achieving their own personal goals for the course. Instructors benefit from easy-to-access reports so they can gain important insights into their students’ expectations, confidence, and personal challenges.
  • New assessment questions were added throughout to support revised and new content, as well as add variety and depth, including engaging in-class activities such as the Great Bear Rainforest and higher-order questions.
  • Interactive questions have been added in every chapter. These questions engage students and provide an added layer of diversity to our assessment collection.

Two new visual syntheses help students see and explore the big picture:

  • History of Earth and Life (Visual Synthesis 7) gives students a sense of time from the formation of Earth to the present. This new visual synthesis helps students place key geologic and biological events in the vast sweep of time since Earth formed, as well as our place in it.
  • Homeostasis (Visual Synthesis 10) helps students see how animals maintain homeostasis for different parameters, emphasizing this fundamental concept and using it to organize the animal anatomy and physiology chapters that follow.
  • All visual syntheses are static figures in the book and interactive maps in Achieve.

A new primer helps students practice scientific skills:

  • A new primer on Water Chemistry and Movement is included in our set of primers. Primers allow students to practice scientific skills using basic concepts of Scientific Inquiry, Quantitative Reasoning, Probability and Statistics, Data and Data Visualization, Phylogenetic Trees, and Models.

Supporting every student for success in Biology

Biology: How Life Works teaches biology as a story, emphasizing how biology concepts connect with each other so that we better understand the wonder and beauty of life on Earth.

How Life Works is supported in Achieve, Macmillan’s online learning system. Achieve supports students of all levels of preparedness with powerful content suitable for pre-class preparation, in-class active learning, and post-class assessment and self-study.

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James Morris; Daniel Hartl; Andrew Knoll; Robert Lue; Melissa Michael; Andrew Berry; Andrew Biewener; Brian Farrell; N. Michele Holbrook; Jessica Liu; Jean Heitz; Mark Hens; Elena Lozovsky; John Merrill; Randall Phillis; Debra Pires | Fourth Edition | ©2023 | ISBN:9781319387419

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