Cover: Introduction to Genetic Analysis, Digital Update, 12th Edition by Anthony Griffiths; John Doebley; Catherine Peichel; David A. Wassarman

Introduction to Genetic Analysis, Digital Update

Twelfth Edition ©2025 Anthony Griffiths; John Doebley; Catherine Peichel; David A. Wassarman

The 12th edition ofIntroduction to Genetic Analysistakes this cornerstone textbook to the next level. The hallmark focuses on genetic analysis, quantitative problem solving, and experimentation continue in this new edition while incorporating robust updates to the science.

Int...

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ISBN:9781319525194

ISBN:9781319525248

ISBN:9781319600938

Cover: Introduction to Genetic Analysis, Digital Update, 12th Edition by Anthony Griffiths; John Doebley; Catherine Peichel; David A. Wassarman

The evolution of a classic

The 12th edition ofIntroduction to Genetic Analysistakes this cornerstone textbook to the next level. The hallmark focuses on genetic analysis, quantitative problem solving, and experimentation continue in this new edition while incorporating robust updates to the science.

Introduction to Genetic Analysis is supported in Achieve, Macmillan’s new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for biology students. It houses all of our renowned assessments, multimedia assets, e-books, and instructor resources in a powerful new platform. Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding content provides an unrivaled learning experience.

Features

Acclaimed Problem Sets are a hallmark feature of Introduction to Genetic Analysis. These include: 
  • Working with the Figures are questions that prompt students to examine book figures and tease out important information, understand the intricacies of an experimental protocol, relate concepts, or draw a conclusion about what is shown. 
  • Unpacking the Problem (also available in SaplingPlus) are step-by-step tutorials helping students approach a challenging problem. In the book, this is a list of questions shaped around “what do we know and what are we trying to find out”; in Sapling these are interactive tutorials that break the problems down into more approachable steps and build to the final answer.
  • Genetics and Society Questions at the end of each chapter asking students to consider the societal relevance of a topic in the chapter; good for initiating classroom discussion.
  • Basic Problems, are problem-solving or conceptual problems at varying levels for students to practice applying knowledge gained from the chapter. 
  • Challenging Problems are more complex questions, sometimes requiring the application of knowledge from multiple sections of the chapter, or thought questions that spur discussion
Learning Objectives tied to the chapter sections titles, Key Concepts, and EOC questions to help create a learning path for the student (learning path is found in the study guide)

Key concepts - short highlighted features that summarize and reinforce important points from the text. Many more than in 11e, about one per B-head, so that students can always zero in on the relevance of a section.

Model Organism boxes describe key features of a model organism, in particular how it is used to study a particular system, what types of experiments are done with it, or why it serves as a good model for the studies described in the main text.

Numbered boxes go into more depth on a topic described in the text, such as the mathematical derivation behind a population genetics equation or how to map a centromere using linear tetrads.

Solved problems - a few sample problems showing students how to approach and solve the types of questions found in the EOC

New to This Edition

Key Content Changes Coming this Fall 2024
                  
  • Selected figures throughout have been changed to improve accessibility.
  • Throughout the book, photos, figures, and language have been revised to be more inclusive and diverse.
    • New Figure 1-23 on Steps involved in creating and applying polygenic risk scores.
    • Box 4-1 "A Mapping Function" has been updated by deletion of the Perkins formula.
    • There is a new Figure 4-13 on Haldane's mapping function.
    • Section 4.4 is now called Assembling Genome-Wide Linkage Maps; under this, a new subsection has been added on "Big Data Analysis and Linkage Maps."
    • Section 4.6 is now called Using Linkage Maps in Conjunction with Physical Maps; the reworked section includes the addition of fine-mapping and a new Figure 4-17 on Fine-mapping of the cystic fibrosis gene
    • Section 10.4: Engineering Genomes, the CRISPR genome engineering section has been updated and the title changed to “CRISPR genome editing.”
    • New subsections have been added on “CRISPR base editing and transcription regulation,” “Controlling gene expression by RNAi knockout,” and “CRISPR and RNAi are versatile tools for reverse genetics.”
    • New Figure 10.30 on “CRISPR base editing” and Figure 10.31 on “CRISPR transcription modeling.”
    • Three questions have been added on the three new figures.
    • Section 14.1: The Genomics Revolution, there is a new Figure 14-3 showing “Exponential decrease in DNA sequencing costs and increase in data storage needs.”
    • Section 14.2: Obtaining the Sequence of a Genome, there is a new section on “Third-generation sequencing,” with a new Figure 14-11 called PacBio HiFi DNA sequencing.
    • Section 14.5: The Comparative Genomics of Humans with Other Species, Box 14-1 on “Direct-to-Consumer Genetics Testing” has been updated, and there is a new subsection on “Cancer Genomics.”
    • Section 14.7: Functional Genomics, updated information on third-generation RNA-seq and ChIP-seq techniques has been added.
    • There is a new solved problem on the subtypes of breast cancer.
    • Section 19.5: Association Mapping in Random-Mating Populations, there is new text under “GWA, genes, disease, and heritability that updates the study of the genetics of human height variation.
Special Topics in Genetics: The Genetic Architecture of Cancer
  • This new separate section pulls together all of the places in the text that cover the genetics of cancer and provides an overview of the diseases that make up cancer. Subsections include “Cancer Is a Genetic Disease,” “Cancer Is a Developmental Disease,” and “Cancer Is a Genomic Disease.”
Special Topics in Genetics: SARS-CoV-19
  • This new separate section discusses the genetics of SARS-CoV-19, the virus that causes COVID-19. Subsections include “Overview of SARS-CoV-19 and Other Coronaviruses,” “Structure of Coronaviruses,” “Life Cycle of SAR-CoV-19,” “Genome Replication, Capping, and Polyadenylation,” “Transcription,” “Translation,” “Evolution of SARS-CoV-19,” “Detection of SARS-CoV-19,” and “SARS-CoV-19 Vaccines.”

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Table of Contents

1   The Genetics Revolution in the Life Sciences
2   Single-Gene Inheritance
3   Independent Assortment of Genes
4   Mapping Eukaryote Chromosomes by Recombination
5   Gene Interaction
6   The Genetics of Bacteria and Their Viruses
7   DNA: Structure and Replication
8   RNA: Transcription and Processing
9   Proteins and Their Synthesis
10  Gene Isolation and Manipulation
11  Regulation of Gene Expression in Bacteria and Their Viruses
12  Regulation of Transcription in Eukaryotes
13  The Genetic Control of Development
14  Genomes and Genomics
15  Mutation, Repair, and Recombination
16  The Dynamic Genome: Transposable Elements
17  Large-Scale Chromosomal Changes
18  Population Genetics
19  The Inheritance of Complex Traits
20  Evolution of Genes, Traits, and Species
Headshot of Anthony J.F. Griffiths

Anthony J.F. Griffiths

Anthony Griffiths is a Professor of Botany, Emeritus, at the University of British Columbia. His research focuses on the developmental genetics of fungi, using the model fungus Neurospora crassa. He has served as President of the Genetics Society of Canada and Secretary-General of the International Genetics Federation.

Headshot of John Doebley

John Doebley

John Doebley is a Professor of Genetics at the University of Wisconsin-Madison. He studies the genetics of crop domestication, using the methods of population and quantitative genetics. He was elected to the National Academy of Sciences in 2003 and served as the President of the American Genetic Association in 2005. He teaches General Genetics at the University of Wisconsin.

Headshot of Catherine Peichel

Catherine Peichel

Catherine L. Peichel is a Professor of Evolutionary Ecology at the University of Bern, Switzerland. She studies the genetic, developmental and genomic mechanisms that underlie evolutionary processes using stickleback fish as a model system. Dr. Peichel was named a Fellow of the John Simon Guggenheim Memorial Foundation in 2013 and served as President of the American Genetic Association in 2015. She teaches evolutionary biology at the University of Bern.

Headshot of David A. Wassarman

David A. Wassarman

David A. Wassarman is a Professor of Medical Genetics at the University of Wisconsin-Madison. His research focuses on the genetics of neurodegenerative diseases using Drosophila melanogaster. In 1997, he was awarded the Presidential Early Career Award for Scientists and Engineers. He teaches molecular genetics at the University of Wisconsin-Madison.

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Anthony Griffiths; John Doebley; Catherine Peichel; David A. Wassarman | Twelfth Edition | ©2025 | ISBN:9781319525415

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