Introduction to Genetic Analysis
Twelfth Edition ©2020 Anthony Griffiths; John Doebley; Catherine Peichel; David A. Wassarman Formats: Achieve, E-book, Print
As low as $74.99
As low as $74.99
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Authors
-
Anthony J.F. Griffiths
Anthony Griffiths is a Professor of Botany, Emeritus, at the University of British Columbia. His research focuses on the developmental genetics of fungi, using the model fungus Neurospora crassa. He has served as President of the Genetics Society of Canada and Secretary-General of the International Genetics Federation.
-
John Doebley
John Doebley is a Professor of Genetics at the University of Wisconsin-Madison. He studies the genetics of crop domestication, using the methods of population and quantitative genetics. He was elected to the National Academy of Sciences in 2003 and served as the President of the American Genetic Association in 2005. He teaches General Genetics at the University of Wisconsin.
-
Catherine Peichel
Catherine L. Peichel is a Professor of Evolutionary Ecology at the University of Bern, Switzerland. She studies the genetic, developmental and genomic mechanisms that underlie evolutionary processes using stickleback fish as a model system. Dr. Peichel was named a Fellow of the John Simon Guggenheim Memorial Foundation in 2013 and served as President of the American Genetic Association in 2015. She teaches evolutionary biology at the University of Bern.
-
David A. Wassarman
David A. Wassarman is a Professor of Medical Genetics at the University of Wisconsin-Madison. His research focuses on the genetics of neurodegenerative diseases using Drosophila melanogaster. In 1997, he was awarded the Presidential Early Career Award for Scientists and Engineers. He teaches molecular genetics at the University of Wisconsin-Madison.
Table of Contents
1 The Genetics Revolution in the Life Sciences
2 Single-Gene Inheritance
3 Independent Assortment of Genes
4 Mapping Eukaryote Chromosomes by Recombination
5 Gene Interaction
6 The Genetics of Bacteria and Their Viruses
7 DNA: Structure and Replication
8 RNA: Transcription and Processing
9 Proteins and Their Synthesis
10 Gene Isolation and Manipulation
11 Regulation of Gene Expression in Bacteria and Their Viruses
12 Regulation of Transcription in Eukaryotes
13 The Genetic Control of Development
14 Genomes and Genomics
15 Mutation, Repair, and Recombination
16 The Dynamic Genome: Transposable Elements
17 Large-Scale Chromosomal Changes
18 Population Genetics
19 The Inheritance of Complex Traits
20 Evolution of Genes, Traits, and Species
Product Updates
Selected figures throughout have been changed to improve accessibility.
- New Figure 1-23 on Steps involved in creating and applying polygenic risk scores.
- Box 4-1 "A Mapping Function" has been updated by deletion of the Perkins formula.
- There is a new Figure 4-13 on Haldane's mapping function.
- Section 4.4 is now called Assembling Genome-Wide Linkage Maps; under this, a new subsection has been added on "Big Data Analysis and Linkage Maps."
- Section 4.6 is now called Using Linkage Maps in Conjunction with Physical Maps; the reworked section includes the addition of fine-mapping and a new Figure 4-17 on Fine-mapping of the cystic fibrosis gene
- Section 10.4: Engineering Genomes, the CRISPR genome engineering section has been updated and the title changed to “CRISPR genome editing.”
- New subsections have been added on “CRISPR base editing and transcription regulation,” “Controlling gene expression by RNAi knockout,” and “CRISPR and RNAi are versatile tools for reverse genetics.”
- New Figure 10.30 on “CRISPR base editing” and Figure 10.31 on “CRISPR transcription modeling.”
- Three questions have been added on the three new figures.
- Section 14.1: The Genomics Revolution, there is a new Figure 14-3 showing “Exponential decrease in DNA sequencing costs and increase in data storage needs.”
- Section 14.2: Obtaining the Sequence of a Genome, there is a new section on “Third-generation sequencing,” with a new Figure 14-11 called PacBio HiFi DNA sequencing.
- Section 14.5: The Comparative Genomics of Humans with Other Species, Box 14-1 on “Direct-to-Consumer Genetics Testing” has been updated, and there is a new subsection on “Cancer Genomics.”
- Section 14.7: Functional Genomics, updated information on third-generation RNA-seq and ChIP-seq techniques has been added.
- There is a new solved problem on the subtypes of breast cancer.
- Section 19.5: Association Mapping in Random-Mating Populations, there is new text under “GWA, genes, disease, and heritability that updates the study of the genetics of human height variation.
- This new separate section pulls together all of the places in the text that cover the genetics of cancer and provides an overview of the diseases that make up cancer. Subsections include “Cancer Is a Genetic Disease,” “Cancer Is a Developmental Disease,” and “Cancer Is a Genomic Disease.”
- This new separate section discusses the genetics of SARS-CoV-19, the virus that causes COVID-19. Subsections include “Overview of SARS-CoV-19 and Other Coronaviruses,” “Structure of Coronaviruses,” “Life Cycle of SAR-CoV-19,” “Genome Replication, Capping, and Polyadenylation,” “Transcription,” “Translation,” “Evolution of SARS-CoV-19,” “Detection of SARS-CoV-19,” and “SARS-CoV-19 Vaccines.”
Twelfth Edition Updates:
Introduction to Genetic Analysis is now supported in Achieve, Macmillan’s new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for biology students. It houses all of our renowned assessments, multimedia assets, e-books, and instructor resources in a powerful new platform.
The 12th edition introduces two new co-authors to the team:
- David Wassarman improved clarity and organization of the molecular genetics content through an extensive revision. mRNA degradation is new to this edition. RNAi and RNA silencing topics have been reorganized and revised for clarity. Genetics techniques in Chapters 10 and 14 have been updated to include CRISPR and next-generation sequencing techniques, among others.
- Catherine Peichel brings a modern evolutionary genetics approach to Chapters 13, 17, and 20. She introduces the use of non-model organisms in evolutionary and developmental genetics research, and how modern genetics techniques allows these studies.
Content updates:
- The molecular genetics chapters (7-12) have been heavily revised. As revised, they relate only the fundamental mechanics of molecular genetics, while keeping the experimental basis for how these discoveries were made. In particular, Chapter 8 now tells the life cycle of an RNA, from synthesis to decay, and includes important events such as mRNA editing, nucleotide modification, nuclear export, and decay (all not previously in IGA). Chapter 12 was also reorganized and streamlined to build from the roles of transcription factors in transcriptional regulation to the structure of chromatin and how chromatin modifications and chromatin rearrangement affect transcription in both short-term and long-term situations.
- Genetics techniques updates. Chapter 10 (Gene Isolation and Manipulation) was updated to include more modern molecular genetics techniques, most notably CRISPR/Cas9. The chapter weaves the story of insulin as an example of how a human gene can be isolated and manipulated to allow its large-scale production for use in medicine. Katie updated Chapter 14 Genome and Genomics to include much-needed updates to next-generation sequencing techniques (e.g., Illumina sequencing) and bioinformatics approaches to analyzing human genomes.
- Chapters 13, 17, and 20 have been updated to include more about non-model organisms. Modern genetics and genomics techniques allow the study of non-traditional model organisms, expanding the ability to study unique systems in the most representative organisms. Also new is an addition to the Model Organisms Appendix entitled, “Beyond Model Organisms.”
Chapter objectives - New to 12e, each chapter begins with a short (2-sentence paragraph) describing the goals of the chapter and placing the chapter topic into context of the surrounding chapters. This helps students “see the forest” before stepping into the “trees”.
Part introductions (core principles) - New to 12th edition, the three parts of the book (transmission genetics, molecular genetics, and evolutionary genetics) begins with a short (3-5ish page) introduction outlining the core principles that undergird that segment of genetics. These help orient students by providing an overview of the themes they’ll encounter as they read each part.
Study guides - are short outlines of the Learning Objectives from each chapter, aligned with the relevant text, figures, and tables; key terms, key concepts, and EOC questions. Each LO found in the chapter is supported with a list of subtasks, the skills or understanding students should gain when reading the relevant sections of text. Using this study guide as a learning path, students can check that they’ve achieved the stated goals in each section, find gaps in their knowledge, and identify the sections they need to study in order to fill those gaps.
Authors
-
Anthony J.F. Griffiths
Anthony Griffiths is a Professor of Botany, Emeritus, at the University of British Columbia. His research focuses on the developmental genetics of fungi, using the model fungus Neurospora crassa. He has served as President of the Genetics Society of Canada and Secretary-General of the International Genetics Federation.
-
John Doebley
John Doebley is a Professor of Genetics at the University of Wisconsin-Madison. He studies the genetics of crop domestication, using the methods of population and quantitative genetics. He was elected to the National Academy of Sciences in 2003 and served as the President of the American Genetic Association in 2005. He teaches General Genetics at the University of Wisconsin.
-
Catherine Peichel
Catherine L. Peichel is a Professor of Evolutionary Ecology at the University of Bern, Switzerland. She studies the genetic, developmental and genomic mechanisms that underlie evolutionary processes using stickleback fish as a model system. Dr. Peichel was named a Fellow of the John Simon Guggenheim Memorial Foundation in 2013 and served as President of the American Genetic Association in 2015. She teaches evolutionary biology at the University of Bern.
-
David A. Wassarman
David A. Wassarman is a Professor of Medical Genetics at the University of Wisconsin-Madison. His research focuses on the genetics of neurodegenerative diseases using Drosophila melanogaster. In 1997, he was awarded the Presidential Early Career Award for Scientists and Engineers. He teaches molecular genetics at the University of Wisconsin-Madison.
Table of Contents
1 The Genetics Revolution in the Life Sciences
2 Single-Gene Inheritance
3 Independent Assortment of Genes
4 Mapping Eukaryote Chromosomes by Recombination
5 Gene Interaction
6 The Genetics of Bacteria and Their Viruses
7 DNA: Structure and Replication
8 RNA: Transcription and Processing
9 Proteins and Their Synthesis
10 Gene Isolation and Manipulation
11 Regulation of Gene Expression in Bacteria and Their Viruses
12 Regulation of Transcription in Eukaryotes
13 The Genetic Control of Development
14 Genomes and Genomics
15 Mutation, Repair, and Recombination
16 The Dynamic Genome: Transposable Elements
17 Large-Scale Chromosomal Changes
18 Population Genetics
19 The Inheritance of Complex Traits
20 Evolution of Genes, Traits, and Species
Product Updates
Selected figures throughout have been changed to improve accessibility.
- New Figure 1-23 on Steps involved in creating and applying polygenic risk scores.
- Box 4-1 "A Mapping Function" has been updated by deletion of the Perkins formula.
- There is a new Figure 4-13 on Haldane's mapping function.
- Section 4.4 is now called Assembling Genome-Wide Linkage Maps; under this, a new subsection has been added on "Big Data Analysis and Linkage Maps."
- Section 4.6 is now called Using Linkage Maps in Conjunction with Physical Maps; the reworked section includes the addition of fine-mapping and a new Figure 4-17 on Fine-mapping of the cystic fibrosis gene
- Section 10.4: Engineering Genomes, the CRISPR genome engineering section has been updated and the title changed to “CRISPR genome editing.”
- New subsections have been added on “CRISPR base editing and transcription regulation,” “Controlling gene expression by RNAi knockout,” and “CRISPR and RNAi are versatile tools for reverse genetics.”
- New Figure 10.30 on “CRISPR base editing” and Figure 10.31 on “CRISPR transcription modeling.”
- Three questions have been added on the three new figures.
- Section 14.1: The Genomics Revolution, there is a new Figure 14-3 showing “Exponential decrease in DNA sequencing costs and increase in data storage needs.”
- Section 14.2: Obtaining the Sequence of a Genome, there is a new section on “Third-generation sequencing,” with a new Figure 14-11 called PacBio HiFi DNA sequencing.
- Section 14.5: The Comparative Genomics of Humans with Other Species, Box 14-1 on “Direct-to-Consumer Genetics Testing” has been updated, and there is a new subsection on “Cancer Genomics.”
- Section 14.7: Functional Genomics, updated information on third-generation RNA-seq and ChIP-seq techniques has been added.
- There is a new solved problem on the subtypes of breast cancer.
- Section 19.5: Association Mapping in Random-Mating Populations, there is new text under “GWA, genes, disease, and heritability that updates the study of the genetics of human height variation.
- This new separate section pulls together all of the places in the text that cover the genetics of cancer and provides an overview of the diseases that make up cancer. Subsections include “Cancer Is a Genetic Disease,” “Cancer Is a Developmental Disease,” and “Cancer Is a Genomic Disease.”
- This new separate section discusses the genetics of SARS-CoV-19, the virus that causes COVID-19. Subsections include “Overview of SARS-CoV-19 and Other Coronaviruses,” “Structure of Coronaviruses,” “Life Cycle of SAR-CoV-19,” “Genome Replication, Capping, and Polyadenylation,” “Transcription,” “Translation,” “Evolution of SARS-CoV-19,” “Detection of SARS-CoV-19,” and “SARS-CoV-19 Vaccines.”
Twelfth Edition Updates:
Introduction to Genetic Analysis is now supported in Achieve, Macmillan’s new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for biology students. It houses all of our renowned assessments, multimedia assets, e-books, and instructor resources in a powerful new platform.
The 12th edition introduces two new co-authors to the team:
- David Wassarman improved clarity and organization of the molecular genetics content through an extensive revision. mRNA degradation is new to this edition. RNAi and RNA silencing topics have been reorganized and revised for clarity. Genetics techniques in Chapters 10 and 14 have been updated to include CRISPR and next-generation sequencing techniques, among others.
- Catherine Peichel brings a modern evolutionary genetics approach to Chapters 13, 17, and 20. She introduces the use of non-model organisms in evolutionary and developmental genetics research, and how modern genetics techniques allows these studies.
Content updates:
- The molecular genetics chapters (7-12) have been heavily revised. As revised, they relate only the fundamental mechanics of molecular genetics, while keeping the experimental basis for how these discoveries were made. In particular, Chapter 8 now tells the life cycle of an RNA, from synthesis to decay, and includes important events such as mRNA editing, nucleotide modification, nuclear export, and decay (all not previously in IGA). Chapter 12 was also reorganized and streamlined to build from the roles of transcription factors in transcriptional regulation to the structure of chromatin and how chromatin modifications and chromatin rearrangement affect transcription in both short-term and long-term situations.
- Genetics techniques updates. Chapter 10 (Gene Isolation and Manipulation) was updated to include more modern molecular genetics techniques, most notably CRISPR/Cas9. The chapter weaves the story of insulin as an example of how a human gene can be isolated and manipulated to allow its large-scale production for use in medicine. Katie updated Chapter 14 Genome and Genomics to include much-needed updates to next-generation sequencing techniques (e.g., Illumina sequencing) and bioinformatics approaches to analyzing human genomes.
- Chapters 13, 17, and 20 have been updated to include more about non-model organisms. Modern genetics and genomics techniques allow the study of non-traditional model organisms, expanding the ability to study unique systems in the most representative organisms. Also new is an addition to the Model Organisms Appendix entitled, “Beyond Model Organisms.”
Chapter objectives - New to 12e, each chapter begins with a short (2-sentence paragraph) describing the goals of the chapter and placing the chapter topic into context of the surrounding chapters. This helps students “see the forest” before stepping into the “trees”.
Part introductions (core principles) - New to 12th edition, the three parts of the book (transmission genetics, molecular genetics, and evolutionary genetics) begins with a short (3-5ish page) introduction outlining the core principles that undergird that segment of genetics. These help orient students by providing an overview of the themes they’ll encounter as they read each part.
Study guides - are short outlines of the Learning Objectives from each chapter, aligned with the relevant text, figures, and tables; key terms, key concepts, and EOC questions. Each LO found in the chapter is supported with a list of subtasks, the skills or understanding students should gain when reading the relevant sections of text. Using this study guide as a learning path, students can check that they’ve achieved the stated goals in each section, find gaps in their knowledge, and identify the sections they need to study in order to fill those gaps.
The evolution of a classic
The new 12th edition of Introduction to Genetic Analysis takes this cornerstone textbook to the next level. The hallmark focuses on genetic analysis, quantitative problem solving, and experimentation continue in this new edition while incorporating robust updates to the science.
Introduction to Genetic Analysis is now supported in Achieve, Macmillan’s new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for biology students. It houses all of our renowned assessments, multimedia assets, e-books, and instructor resources in a powerful new platform.
Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding content provides an unrivaled learning experience.
Success Stories
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Anthony Griffiths; John Doebley; Catherine Peichel; David A. Wassarman | Twelfth Edition | ©2020 | ISBN:9781319337810
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If you’re a verified instructor, you can request a free sample of our courseware, e-book, or print textbook to consider for use in your courses. Only registered and verified instructors can receive free print and digital samples, and they should not be sold to bookstores or book resellers. If you don't yet have an existing account with Macmillan Learning, it can take up to two business days to verify your status as an instructor. You can request a free sample from the right side of this product page by clicking on the "Request Instructor Sample" button or by contacting your rep. Learn more.
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Sometimes also referred to as a spiral-bound or binder-ready textbook, loose-leaf textbooks are available to purchase. This three-hole punched, unbound version of the book costs less than a hardcover or paperback book.
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Achieve (full course) includes our complete e-book, as well as online quizzing tools, multimedia assets, and iClicker active classroom manager.
Most Achieve Essentials courses do not include our e-books and adaptive quizzing.
Visit our comparison table for details: https://www.macmillanlearning.com/college/us/digital/achieve/compare
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Achieve (full course) includes our complete e-book, as well as online quizzing tools, multimedia assets, and iClicker active classroom manager.
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Introduction to Genetic Analysis
The new 12th edition of Introduction to Genetic Analysis takes this cornerstone textbook to the next level. The hallmark focuses on genetic analysis, quantitative problem solving, and experimentation continue in this new edition while incorporating robust updates to the science.
Introduction to Genetic Analysis is now supported in Achieve, Macmillan’s new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for biology students. It houses all of our renowned assessments, multimedia assets, e-books, and instructor resources in a powerful new platform.
Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding content provides an unrivaled learning experience.
These materials are owned by Macmillan Learning or its licensors and are protected by United States copyright law. They are being provided solely for evaluation purposes only by instructors who are considering adopting Macmillan Learning's textbooks or online products for use by students in their courses. These materials may not be copied, distributed, sold, shared, posted online, or used, in print or electronic format, except in the limited circumstances set forth in the Macmillan Learning Terms of Use and any other reproduction or distribution is illegal. These materials may not be made publicly available under any circumstances. All other rights reserved. © 2020 Macmillan Learning.
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