Molecular Biology
Second Edition ©2015 Michael M. Cox; Jennifer Doudna; Michael O'Donnell Formats: Achieve, E-book, Print
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Authors
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Michael Cox
Michael M. Cox was born in Wilmington, Delaware. In his first biochemistry course, the first edition of Lehninger's Biochemistry was a major influence in refocusing his fascination with biology and inspiring him to pursue a career in biochemistry. After graduate work at Brandeis University with William P. Jencks and post-doctoral work at Stanford with I. Robert Lehman, he moved to the University of Wisconsin–Madison in 1983. He became a full professor of Biochemistry in 1992.
Mike Cox has coordinated an active research team at Wisconsin investigating the function and mechanism of enzymes that act at the interface of DNA replication, repair, and recombination. That work has resulted in over 200 publications to date.
For more than three decades, Cox has taught introductory biochemistry to undergraduates and has lectured in a variety of graduate courses. He organized a course on professional responsibility for first-year graduate students and established a systematic program to draw talented biochemistry undergraduates into the laboratory at an early stage of their college career. He has received multiple awards for both his teaching and his research, including the Eli Lilly Award in Biological Chemistry, election as an AAAS fellow, and the UW Regents Teaching Excellence Award. Cox's hobbies include turning 18 acres of Wisconsin farmland into an arboretum, wine collecting, and assisting in the design of laboratory buildings.
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Jennifer Doudna
Jennifer A. Doudna grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in biochemistry from Pomona College and her Ph.D. from Harvard University, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research. She next went to the University of Colorado as a Lucille P. Markey scholar and postdoctoral fellow with Thomas Cech. Doudna has also been a Donaghue Young Investigator, a Searle scholar, and a Beckman Young Investigator, and she is a former fellow of the David and Lucile Packard Foundation. She has received numerous awards for her research on RNA and RNA-protein structure and function, including the Johnson Foundation Prize for innovative research, the National Academy of Sciences Award for initiatives in research, the Alan T. Waterman Award from the National Science Foundation, and the Eli Lilly Award in Biological Chemistry from the American Chemical Society. She is a member of the Scientific Advisory Board of the David and Lucile Packard Foundation and a Trustee of Pomona College. Doudna is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is also a Fellow of the American Association for the Advancement of Science. Jennifer is the recipient of the 2020 Nobel Prize for chemistry for herresearch on CRISPR gene editing.
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Michael O'Donnell
Michael O’Donnell received his Ph.D. at the University of Michigan, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. O’Donnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University in 1996. O’Donnell is a member of the National Academy of Sciences.
Table of Contents
Product Updates
Updated discussions on evolution and the scientific method.
Chapter 2. DNA: The Repository of Biological Information
Updated discussion of the central dogma
Updated and expanded discussion of the types of RNA Chapter 3. Chemical Basis of Information Molecules
New Moment of Discovery
Expanded discussion of nucleosides
Revised and expanded section: The Hydrophobic Effect Brings Together Nonpolar Molecules
New section: Electronic Interactions Between Bases in Nucleic Acids Chapter 4. Protein Structure
Expanded section: Amino Acids Are Categorized by Chemical Properties
Significantly expanded discussion of protein purification, including Highlight 4-1
New section: Intrinsically Unstructured Proteins
Expanded section on protein families
Significantly expanded section on protein folding and computational biology Chapter 5. Protein Function
New Moment of Discovery Chapter 6. DNA and RNA Structure
Expanded discussion of the instability of RNA
New Highlight (6-1 Technology)
New discussion of riboswitches Chapter 7. Studying Genes
Expanded discussion on obtaining DNA fragments to clone
Thoroughly updated section on next-gen and other modern DNA sequencing technologies.
New section on genome editing, incorporating the exciting new advances with programmable nucleases Chapter 8. Genomes, Transcriptomes, and Proteomes
Expanded Highlight 8-1, now including discussion of the microbiome
Updated section on noncoding DNA
Expanded section on mass spectrometry 10. Nucleosomes, Chromatin, and Chromosome Structure
New Moment of Discovery
Significantly expanded discussion of histone modifications, including a new table Chapter 11. DNA Replication
Expanded discussion of the b sliding clamp
Expanded discussion of the Pol III holoenzyme
Updated and expanded discussion of eukaryotic replication forks
Updated and expanded section: Eukaryotic Origins "Fire" Only Once per Cell Cycle
New section: Telomeres and Telomerase Solve the End Replication Problem in Eukaryotes
New Highlight (11-2): Short Telomeres Portend Aging Diseases Chapter 12. DNA Mutation and Repair
New Moment of Discovery
New table (overview of DNA repair processes) Chapter 13. Recombinational DNA Repair and Homologous Recombination
Updated and expanded sections on double-strand break repair and reconstruction of replication forks
Updated section on meiotic recombination Chapter 14. Site-Specific Recombination and Transposition
Updated and expanded introductory section on transposable elements and site-specific recombination
Updated and expanded section: Precise DNA Rearrangements Are Promoted by Site-Specific Recombinases
Reorganized section on the use of site-specific recombination systems in biotechnology
Updated and expanded sections on transposition Chapter 15. Transcription: DNA-Dependent Synthesis of RNA
Updated section on transcription elongation
Updated and expanded discussion on role of transcription factors
Updated and expanded discussion of termination mechanisms among RNA polymerases Chapter 16. RNA Processing
Streamlined chapter organization
Expanded discussion of P bodies Chapter 18. Protein Synthesis
Streamlined chapter organization
Updated discussion on protein release factors
Updated discussion on nuclear export signals Chapter 19. Regulating the Flow of Information
Updated section: Gene Expression Is Regulated through Feedback Loops (now includes inducer exclusion) Chapter 22. The Posttranscriptional Regulation of Gene Expression in Eukaryotes
Expanded section on alternative splicing, including ESEs and ESSs
Updated section on RNA interference
New section: RNAs Regulate a Myriad of Cellular Processes
Updated section on the developmental potential of stem cells New Media
Achieve
Achieve is Macmillan’s next-generation online learning system: a fully mobile, accessible, and flexible learning system. Achieve offers powerful assessment tools and content to support students of all levels of preparation in an intuitive and user-friendly system.
Simulations
Created using the art from the text, the simulations reinforce understanding of core concepts and techniques by letting students interact with the structures and processes that they have encountered. A game-like format guides students through the simulations, and gradable, multiple-choice questions after each one let instructors assess whether students have thoroughly understood them:
- DNA/RNA Structure (Chapter 6)
- PCR (Chapter 7)
- Sanger Sequencing (Chapter 7)
- DNA Replication (Chapter 11)
- DNA Polymerase (Chapter 11)
- Mutation and Repair (Chapter 12)
- Transcription (Chapter 15)
- mRNA Processing (Chapter 16)
- Nucleotide Structure (Chapter 3)
- Translation (Chapter 18)
- CRISPR (Chapter 7 and Chapter 19)
Nature Articles with Assessment
Specifically selected for both alignment with text coverage and exploration of identified difficult topics, the Nature articles include assessment questions that can be automatically graded. Open-ended questions that are suitable for use in flipped classrooms and active learning discussions either in class or online are also included.New Clicker Questions
Instructors can integrate active learning in the classroom and assess students’ understanding of key concepts during lectures.Updated Test Bank
The test bank offers at least 40 multiple-choice and short-answer questions for each chapter.Key Term Flashcards
Students can review the definitions of all of the glossary terms and quiz themselves.Textbook Images and Tables
Available as high-resolution JPEG files, these images have been fully optimized and tested in a large lecture hall to ensure maximum clarity and visibility.
Authors
-
Michael Cox
Michael M. Cox was born in Wilmington, Delaware. In his first biochemistry course, the first edition of Lehninger's Biochemistry was a major influence in refocusing his fascination with biology and inspiring him to pursue a career in biochemistry. After graduate work at Brandeis University with William P. Jencks and post-doctoral work at Stanford with I. Robert Lehman, he moved to the University of Wisconsin–Madison in 1983. He became a full professor of Biochemistry in 1992.
Mike Cox has coordinated an active research team at Wisconsin investigating the function and mechanism of enzymes that act at the interface of DNA replication, repair, and recombination. That work has resulted in over 200 publications to date.
For more than three decades, Cox has taught introductory biochemistry to undergraduates and has lectured in a variety of graduate courses. He organized a course on professional responsibility for first-year graduate students and established a systematic program to draw talented biochemistry undergraduates into the laboratory at an early stage of their college career. He has received multiple awards for both his teaching and his research, including the Eli Lilly Award in Biological Chemistry, election as an AAAS fellow, and the UW Regents Teaching Excellence Award. Cox's hobbies include turning 18 acres of Wisconsin farmland into an arboretum, wine collecting, and assisting in the design of laboratory buildings.
-
Jennifer Doudna
Jennifer A. Doudna grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in biochemistry from Pomona College and her Ph.D. from Harvard University, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research. She next went to the University of Colorado as a Lucille P. Markey scholar and postdoctoral fellow with Thomas Cech. Doudna has also been a Donaghue Young Investigator, a Searle scholar, and a Beckman Young Investigator, and she is a former fellow of the David and Lucile Packard Foundation. She has received numerous awards for her research on RNA and RNA-protein structure and function, including the Johnson Foundation Prize for innovative research, the National Academy of Sciences Award for initiatives in research, the Alan T. Waterman Award from the National Science Foundation, and the Eli Lilly Award in Biological Chemistry from the American Chemical Society. She is a member of the Scientific Advisory Board of the David and Lucile Packard Foundation and a Trustee of Pomona College. Doudna is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is also a Fellow of the American Association for the Advancement of Science. Jennifer is the recipient of the 2020 Nobel Prize for chemistry for herresearch on CRISPR gene editing.
-
Michael O'Donnell
Michael O’Donnell received his Ph.D. at the University of Michigan, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. O’Donnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University in 1996. O’Donnell is a member of the National Academy of Sciences.
Table of Contents
Product Updates
Updated discussions on evolution and the scientific method.
Chapter 2. DNA: The Repository of Biological Information
Updated discussion of the central dogma
Updated and expanded discussion of the types of RNA Chapter 3. Chemical Basis of Information Molecules
New Moment of Discovery
Expanded discussion of nucleosides
Revised and expanded section: The Hydrophobic Effect Brings Together Nonpolar Molecules
New section: Electronic Interactions Between Bases in Nucleic Acids Chapter 4. Protein Structure
Expanded section: Amino Acids Are Categorized by Chemical Properties
Significantly expanded discussion of protein purification, including Highlight 4-1
New section: Intrinsically Unstructured Proteins
Expanded section on protein families
Significantly expanded section on protein folding and computational biology Chapter 5. Protein Function
New Moment of Discovery Chapter 6. DNA and RNA Structure
Expanded discussion of the instability of RNA
New Highlight (6-1 Technology)
New discussion of riboswitches Chapter 7. Studying Genes
Expanded discussion on obtaining DNA fragments to clone
Thoroughly updated section on next-gen and other modern DNA sequencing technologies.
New section on genome editing, incorporating the exciting new advances with programmable nucleases Chapter 8. Genomes, Transcriptomes, and Proteomes
Expanded Highlight 8-1, now including discussion of the microbiome
Updated section on noncoding DNA
Expanded section on mass spectrometry 10. Nucleosomes, Chromatin, and Chromosome Structure
New Moment of Discovery
Significantly expanded discussion of histone modifications, including a new table Chapter 11. DNA Replication
Expanded discussion of the b sliding clamp
Expanded discussion of the Pol III holoenzyme
Updated and expanded discussion of eukaryotic replication forks
Updated and expanded section: Eukaryotic Origins "Fire" Only Once per Cell Cycle
New section: Telomeres and Telomerase Solve the End Replication Problem in Eukaryotes
New Highlight (11-2): Short Telomeres Portend Aging Diseases Chapter 12. DNA Mutation and Repair
New Moment of Discovery
New table (overview of DNA repair processes) Chapter 13. Recombinational DNA Repair and Homologous Recombination
Updated and expanded sections on double-strand break repair and reconstruction of replication forks
Updated section on meiotic recombination Chapter 14. Site-Specific Recombination and Transposition
Updated and expanded introductory section on transposable elements and site-specific recombination
Updated and expanded section: Precise DNA Rearrangements Are Promoted by Site-Specific Recombinases
Reorganized section on the use of site-specific recombination systems in biotechnology
Updated and expanded sections on transposition Chapter 15. Transcription: DNA-Dependent Synthesis of RNA
Updated section on transcription elongation
Updated and expanded discussion on role of transcription factors
Updated and expanded discussion of termination mechanisms among RNA polymerases Chapter 16. RNA Processing
Streamlined chapter organization
Expanded discussion of P bodies Chapter 18. Protein Synthesis
Streamlined chapter organization
Updated discussion on protein release factors
Updated discussion on nuclear export signals Chapter 19. Regulating the Flow of Information
Updated section: Gene Expression Is Regulated through Feedback Loops (now includes inducer exclusion) Chapter 22. The Posttranscriptional Regulation of Gene Expression in Eukaryotes
Expanded section on alternative splicing, including ESEs and ESSs
Updated section on RNA interference
New section: RNAs Regulate a Myriad of Cellular Processes
Updated section on the developmental potential of stem cells New Media
Achieve
Achieve is Macmillan’s next-generation online learning system: a fully mobile, accessible, and flexible learning system. Achieve offers powerful assessment tools and content to support students of all levels of preparation in an intuitive and user-friendly system.
Simulations
Created using the art from the text, the simulations reinforce understanding of core concepts and techniques by letting students interact with the structures and processes that they have encountered. A game-like format guides students through the simulations, and gradable, multiple-choice questions after each one let instructors assess whether students have thoroughly understood them:
- DNA/RNA Structure (Chapter 6)
- PCR (Chapter 7)
- Sanger Sequencing (Chapter 7)
- DNA Replication (Chapter 11)
- DNA Polymerase (Chapter 11)
- Mutation and Repair (Chapter 12)
- Transcription (Chapter 15)
- mRNA Processing (Chapter 16)
- Nucleotide Structure (Chapter 3)
- Translation (Chapter 18)
- CRISPR (Chapter 7 and Chapter 19)
Nature Articles with Assessment
Specifically selected for both alignment with text coverage and exploration of identified difficult topics, the Nature articles include assessment questions that can be automatically graded. Open-ended questions that are suitable for use in flipped classrooms and active learning discussions either in class or online are also included.New Clicker Questions
Instructors can integrate active learning in the classroom and assess students’ understanding of key concepts during lectures.Updated Test Bank
The test bank offers at least 40 multiple-choice and short-answer questions for each chapter.Key Term Flashcards
Students can review the definitions of all of the glossary terms and quiz themselves.Textbook Images and Tables
Available as high-resolution JPEG files, these images have been fully optimized and tested in a large lecture hall to ensure maximum clarity and visibility.
Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped—and who continue to shape—the field today.
Molecular Biology: Principles and Practice is now supported in Achieve. Achieve is Macmillan’s next-generation online learning system: a fully mobile, accessible, and flexible learning system. Achieve offers powerful assessment tools and content to support students of all levels of preparation in an intuitive and user-friendly system.
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Test Bank for Molecular Biology
Michael Cox; Michael O'Donnell; Jennifer Doudna | Second Edition | ©2015 | ISBN:9781464188572
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If you’re a verified instructor, you can request a free sample of our courseware, e-book, or print textbook to consider for use in your courses. Only registered and verified instructors can receive free print and digital samples, and they should not be sold to bookstores or book resellers. If you don't yet have an existing account with Macmillan Learning, it can take up to two business days to verify your status as an instructor. You can request a free sample from the right side of this product page by clicking on the "Request Instructor Sample" button or by contacting your rep. Learn more.
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Sometimes also referred to as a spiral-bound or binder-ready textbook, loose-leaf textbooks are available to purchase. This three-hole punched, unbound version of the book costs less than a hardcover or paperback book.
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Achieve (full course) includes our complete e-book, as well as online quizzing tools, multimedia assets, and iClicker active classroom manager.
Most Achieve Essentials courses do not include our e-books and adaptive quizzing.
Visit our comparison table for details: https://www.macmillanlearning.com/college/us/digital/achieve/compare
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Achieve (full course) includes our complete e-book, as well as online quizzing tools, multimedia assets, and iClicker active classroom manager.
Achieve Read & Practice only includes our e-book and adaptive quizzing, and does not include instructor resources and assignable assessments. Read & Practice does integrate with LMS.
Visit our comparison table for details: https://www.macmillanlearning.com/college/us/digital/achieve/compare
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We can help! Contact your representative to discuss your specific needs for your course. If our off-the-shelf course materials don’t quite hit the mark, we also offer custom solutions made to fit your needs.
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Molecular Biology
Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped—and who continue to shape—the field today.
Molecular Biology: Principles and Practice is now supported in Achieve. Achieve is Macmillan’s next-generation online learning system: a fully mobile, accessible, and flexible learning system. Achieve offers powerful assessment tools and content to support students of all levels of preparation in an intuitive and user-friendly system.
Select a demo to view:
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