Look Inside Look Inside Cover: Molecular Biology, 2nd Edition by Michael M. Cox; Jennifer Doudna; Michael O'Donnell

Molecular Biology

Principles and PracticeSecond Edition ©2015 Michael M. Cox; Jennifer Doudna; Michael O'Donnell

Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlight...

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Look Inside Look Inside Cover: Molecular Biology, 2nd Edition by Michael M. Cox; Jennifer Doudna; Michael O'Donnell

Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped—and who continue to shape—the field today.

Molecular Biology: Principles and Practice is now supported in Achieve. Achieve is Macmillan’s next-generation online learning system: a fully mobile, accessible, and flexible learning system. Achieve offers powerful assessment tools and content to support students of all levels of preparation in an intuitive and user-friendly system.

Features

Achieve
Achieve is Macmillan’s next-generation online learning system: a fully mobile, accessible, and flexible learning system. Achieve offers powerful assessment tools and content to support students of all levels of preparation in an intuitive and user-friendly system.


Moment of Discovery
Each chapter opens with a description of a significant breakthrough in molecular biology relevant to that chapter, as told by the scientist who made the discovery


Key Conventions
These brief paragraphs clearly lay out for students some fundamental principles often glossed over by instructors and textbooks.


How We Know
This end-of-chapter section combines fascinating stories of research and researchers with actual experimental data for students to analyze, often drawing on the work of the scientist featured in the chapter’s "Moment of Discovery."


Problems (including Data Analysis Problem)
Problem sets at the end of each chapter give students the opportunity to think about and work with the chapter’s key ideas. Each problem set\ concludes with a Data Analysis Problem, giving students the crucial experience of interpreting real data from actual research (most often the work described in the "How We Know" section). Solutions to the problems can be found on the companion web site.


Unanswered Questions
A short section at the end of each chapter describes important areas still open to discovery, showing students that even well-covered subjects such as nucleic acid structure and DNA replication are far from fully explored.


Highlights
Throughout each chapter, special features focus on fascinating topics that enhance student understanding of the concepts:

  • Medicine looks at diseases that arise from defects in biochemical pathways, or examples of how concepts learned in molecular biology have contributed drug therapies or other treatments.
  • Technology focuses on cutting-edge molecular biology methods that students will likely be hearing about or even using in the future.
  • Evolution reveals the role of molecular biology research in understanding key biological processes and the connections between organisms.
  • A Closer Look highlights a wide variety of additional, intriguing topics.

New to This Edition

The second edition addresses recent discoveries and advances, corresponding to our ever-changing understanding of molecular biology. In addition to the text updates listed here, there are numerous new figures and photos, along with significantly updated figures in every chapter. There are also new end-of-chapter questions for every chapter and many new Unanswered Questions.

Chapter 1. Evolution, Science, and Molecular Biology
Updated discussions on evolution and the scientific method.

Chapter 2. DNA: The Repository of Biological Information
Updated discussion of the central dogma
Updated and expanded discussion of the types of RNA

Chapter 3. Chemical Basis of Information Molecules
New Moment of Discovery
Expanded discussion of nucleosides
Revised and expanded section: The Hydrophobic Effect Brings Together Nonpolar Molecules
New section: Electronic Interactions Between Bases in Nucleic Acids

Chapter 4. Protein Structure
Expanded section: Amino Acids Are Categorized by Chemical Properties
Significantly expanded discussion of protein purification, including Highlight 4-1
New section: Intrinsically Unstructured Proteins
Expanded section on protein families
Significantly expanded section on protein folding and computational biology

Chapter 5. Protein Function
New Moment of Discovery

Chapter 6. DNA and RNA Structure
Expanded discussion of the instability of RNA
New Highlight (6-1 Technology)
New discussion of riboswitches

Chapter 7. Studying Genes
Expanded discussion on obtaining DNA fragments to clone
Thoroughly updated section on next-gen and other modern DNA sequencing technologies.
New section on genome editing, incorporating the exciting new advances with programmable nucleases

Chapter 8. Genomes, Transcriptomes, and Proteomes
Expanded Highlight 8-1, now including discussion of the microbiome
Updated section on noncoding DNA
Expanded section on mass spectrometry

10. Nucleosomes, Chromatin, and Chromosome Structure
New Moment of Discovery
Significantly expanded discussion of histone modifications, including a new table

Chapter 11. DNA Replication
Expanded discussion of the b sliding clamp
Expanded discussion of the Pol III holoenzyme
Updated and expanded discussion of eukaryotic replication forks
Updated and expanded section: Eukaryotic Origins "Fire" Only Once per Cell Cycle
New section: Telomeres and Telomerase Solve the End Replication Problem in Eukaryotes
New Highlight (11-2): Short Telomeres Portend Aging Diseases

Chapter 12. DNA Mutation and Repair
New Moment of Discovery
New table (overview of DNA repair processes)

Chapter 13. Recombinational DNA Repair and Homologous Recombination
Updated and expanded sections on double-strand break repair and reconstruction of replication forks
Updated section on meiotic recombination

Chapter 14. Site-Specific Recombination and Transposition
Updated and expanded introductory section on transposable elements and site-specific recombination
Updated and expanded section: Precise DNA Rearrangements Are Promoted by Site-Specific Recombinases
Reorganized section on the use of site-specific recombination systems in biotechnology
Updated and expanded sections on transposition

Chapter 15. Transcription: DNA-Dependent Synthesis of RNA
Updated section on transcription elongation
Updated and expanded discussion on role of transcription factors
Updated and expanded discussion of termination mechanisms among RNA polymerases

Chapter 16. RNA Processing
Streamlined chapter organization
Expanded discussion of P bodies

Chapter 18. Protein Synthesis
Streamlined chapter organization
Updated discussion on protein release factors
Updated discussion on nuclear export signals

Chapter 19. Regulating the Flow of Information
Updated section: Gene Expression Is Regulated through Feedback Loops (now includes inducer exclusion)

Chapter 22. The Posttranscriptional Regulation of Gene Expression in Eukaryotes
Expanded section on alternative splicing, including ESEs and ESSs
Updated section on RNA interference
New section: RNAs Regulate a Myriad of Cellular Processes
Updated section on the developmental potential of stem cells

New Media

Achieve
Achieve is Macmillan’s next-generation online learning system: a fully mobile, accessible, and flexible learning system. Achieve offers powerful assessment tools and content to support students of all levels of preparation in an intuitive and user-friendly system.

Simulations
Created using the art from the text, the simulations reinforce understanding of core concepts and techniques by letting students interact with the structures and processes that they have encountered. A game-like format guides students through the simulations, and gradable, multiple-choice questions after each one let instructors assess whether students have thoroughly understood them:

  • DNA/RNA Structure (Chapter 6)
  • PCR (Chapter 7)
  • Sanger Sequencing (Chapter 7)
  • DNA Replication (Chapter 11)
  • DNA Polymerase (Chapter 11)
  • Mutation and Repair (Chapter 12)
  • Transcription (Chapter 15)
  • mRNA Processing (Chapter 16)
  • Nucleotide Structure (Chapter 3)
  • Translation (Chapter 18)
  • CRISPR (Chapter 7 and Chapter 19)

    Nature Articles with Assessment
    Specifically selected for both alignment with text coverage and exploration of identified difficult topics, the Nature articles include assessment questions that can be automatically graded. Open-ended questions that are suitable for use in flipped classrooms and active learning discussions either in class or online are also included.

    New Clicker Questions
    Instructors can integrate active learning in the classroom and assess students’ understanding of key concepts during lectures.

    Updated Test Bank
    The test bank offers at least 40 multiple-choice and short-answer questions for each chapter.

    Key Term Flashcards
    Students can review the definitions of all of the glossary terms and quiz themselves.

    Textbook Images and Tables
    Available as high-resolution JPEG files, these images have been fully optimized and tested in a large lecture hall to ensure maximum clarity and visibility.

Digital Options

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Table of Contents

I. Foundations

1. Evolution, Science, and Molecular Biology

2. DNA: The Repository of Biological Information

3. Chemical Basis of Information Molecules

4. Protein Structure

5. Protein Function

II. Nucleic Acid Structure and Methods

6. DNA and RNA Structure

7. Studying Genes

8. Genomes, Transcriptomes, and Proteomes

9. Topology: Functional Deformations of DNA

10. Nucleosomes, Chromatin, and Chromosome Structure

III. Information Transfer

11. DNA Replication

12. DNA Mutation and Repair

13. Recombinational DNA Repair and Homologous Recombination

14. Site-Specific Recombination and Transposition

15. Transcription: DNA-Dependent Synthesis of RNA

16. RNA Processing

17. The Genetic Code

18. Protein Synthesis

IV. Regulation

19. Regulating the Flow of Information

20. The Regulation of Gene Expression in Bacteria

21. The Transcriptional Regulation of Gene Expression in Eukaryotes

22. The Posttranscriptional Regulation of Gene Expression in Eukaryotes

Appendix: Model Organisms

Glossary

Solutions to Problems

Index

　
Headshot of Michael Cox

Michael Cox

Michael M. Cox was born in Wilmington, Delaware. In his first biochemistry course, the first edition of Lehninger's Biochemistry was a major influence in refocusing his fascination with biology and inspiring him to pursue a career in biochemistry. After graduate work at Brandeis University with William P. Jencks and post-doctoral work at Stanford with I. Robert Lehman, he moved to the University of Wisconsin–Madison in 1983. He became a full professor of Biochemistry in 1992.

Mike Cox has coordinated an active research team at Wisconsin investigating the function and mechanism of enzymes that act at the interface of DNA replication, repair, and recombination. That work has resulted in over 200 publications to date.

For more than three decades, Cox has taught introductory biochemistry to undergraduates and has lectured in a variety of graduate courses. He organized a course on professional responsibility for first-year graduate students and established a systematic program to draw talented biochemistry undergraduates into the laboratory at an early stage of their college career. He has received multiple awards for both his teaching and his research, including the Eli Lilly Award in Biological Chemistry, election as an AAAS fellow, and the UW Regents Teaching Excellence Award. Cox's hobbies include turning 18 acres of Wisconsin farmland into an arboretum, wine collecting, and assisting in the design of laboratory buildings.

Headshot of Jennifer Doudna

Jennifer Doudna

Jennifer A. Doudna grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in biochemistry from Pomona College and her Ph.D. from Harvard University, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research. She next went to the University of Colorado as a Lucille P. Markey scholar and postdoctoral fellow with Thomas Cech. Doudna has also been a Donaghue Young Investigator, a Searle scholar, and a Beckman Young Investigator, and she is a former fellow of the David and Lucile Packard Foundation. She has received numerous awards for her research on RNA and RNA-protein structure and function, including the Johnson Foundation Prize for innovative research, the National Academy of Sciences Award for initiatives in research, the Alan T. Waterman Award from the National Science Foundation, and the Eli Lilly Award in Biological Chemistry from the American Chemical Society. She is a member of the Scientific Advisory Board of the David and Lucile Packard Foundation and a Trustee of Pomona College. Doudna is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is also a Fellow of the American Association for the Advancement of Science. Jennifer is the recipient of the 2020 Nobel Prize for chemistry for herresearch on CRISPR gene editing.

Headshot of Michael O'Donnell

Michael O'Donnell

Michael O’Donnell received his Ph.D. at the University of Michigan, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. O’Donnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University in 1996. O’Donnell is a member of the National Academy of Sciences.

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Michael Cox; Michael O'Donnell; Jennifer Doudna | Second Edition | ©2015 | ISBN:9781464188572

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