NEW

Biochemistry: A Short Course

Fifth Edition

Publication Date: February 27, 2025

Paperback ISBN: 9781319498481

Pages: 992

Unleash the real-world potential of a biochemistry education

Dive into biochemistry with clarity and confidence, and see how recent breakthroughs are transforming our understanding of this dynamic field. This engaging text connects core concepts to health, medicine, and related fields helping undergraduates master biochemistry fundamentals. With clear...

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Chapter 1 – Biochemical Similarities Demonstrate the Unity of Life

Chapter 2 – Water, Weak Interactions, and the Generation of Order out of Chaos

Chapter 3 – Amino Acids

Chapter 4 – Protein Three-Dimensional Structure

Chapter 5 – Protein Binding, Molecular Recognition, and Allostery

Chapter 6 – Techniques in Protein Biochemistry

Chapter 7 – Basic Concepts of Enzyme Action

Chapter 8 – Kinetics and Regulation

Chapter 9 – Mechanisms and Inhibitors

Chapter 10 – Carbohydrates

Chapter 11 – Lipids

Chapter 12 – Membrane Structure and Function

Chapter 13 – Signal-Transduction Pathways

Chapter 14 – Digestion: Turning a Meal into Cellular Biochemicals

Chapter 15 – Metabolism: Basic Concepts and Themes

Chapter 16 – Glycolysis

Chapter 17 – Gluconeogenesis

Chapter 18 – Preparation for the Citric Acid Cycle

Chapter 19 – The Citric Acid Cycle

Chapter 20 – The Electron-Transport Chain

Chapter 21 – The Proton-Motive Force

Chapter 22 – Phototrophy and the Light Reactions of Photosynthesis

Chapter 23 – The Calvin–Benson Cycle

Chapter 24 – Glycogen Degradation

Chapter 25 – Glycogen Synthesis

Chapter 26 – The Pentose Phosphate Pathway

Chapter 27 – Fatty Acid and Triacylglycerol Degradation

Chapter 28 – Fatty Acid Synthesis

Chapter 29 – Lipid Synthesis: Storage Lipids, Phospholipids, and Cholesterol

Chapter 30 – Protein Turnover and Amino Acid Catabolism

Chapter 31 – Amino Acid Synthesis

Chapter 32 – Nucleotide Metabolism

Chapter 33 – The Structure of Nucleic Acids: DNA and RNA

Chapter 34 – DNA Replication

Chapter 35 – DNA Repair and Recombination

Chapter 36 – RNA Synthesis and Regulation in Bacteria

Chapter 37 – Gene Expression in Eukaryotes

Chapter 38 – RNA Processing in Eukaryotes

Chapter 39 – The Genetic Code

Chapter 40 – The Mechanism of Protein Synthesis

Chapter 41 – Recombinant DNA Techniques

One Idea at a Time figures and captions make complex biochemistry concepts clear and accessible, enhancing student understanding by focusing on single ideas without distractions.
New Self-Check questions and Worked Examples provide practical tools for assessing comprehension and applying problem-solving techniques, helping students develop critical thinking skills.
New Skills You Need Activities refresh foundational knowledge, while thorough End-of-Chapter questions offer detailed feedback and solutions, ensuring students are well-prepared and confident in their grasp of the material.
New Active Lecture Slides, and Transition Guides from the previous edition, support instructors with customizable teaching tools and ensure effective and current lessons for students.

Achieve is Macmillan Learning’s complete online learning system. It houses instructor resources to support teaching and a range of interactive resources and the full ebook to help students succeed in their course. Access to Achieve for instructors is available on this page. Student access to Achieve could be through their institution if the institution has signed a licence or as a separate student purchase. The instructor must set up a course for students to benefit from this product.

New Self-Check questions and Worked Examples provide practical tools for assessing comprehension and applying problem-solving techniques, helping students develop critical thinking skills.
New Skills You Need Activities refresh foundational knowledge, while thorough End-of-Chapter questions offer detailed feedback and solutions, ensuring students are well-prepared and confident in their grasp of the material.
New Active Lecture Slides, and Transition Guides from the previous edition, support instructors with customizable teaching tools and ensure effective and current lessons for students.

“The worked problems are fun to work. The questions are framed in a highly energetic way. The questions can be presented as discussion questions so that students can analyze themselves before getting the answer.”

– Yan Zhang, The University of Texas at Austin

“I also appreciated the real life examples that were stated and that students could immediately relate to such as the microbiome, food production such as yogurt, diseases such as diabetes.”

– Michelle MacDonald, McMaster University, Hamilton

“The "Clinical Insight" sidebars provide a nice real life connection to a topic that could have devolved into nothing more than memorizing of facts, figures and formula.”

– Newton Hilliard, Arkansas Tech University

Justin Hines

Justin K. Hines is Professor of Chemistry at Lafayette College, where he teaches general chemistry and biochemistry courses and conducts education and NIH-funded laboratory research on protein misfolding with undergraduates. He received both his B.S. and PhD in Biochemistry from Iowa State University, where he studied the structure and regulation of the enzymes of central metabolism with Richard B. Honzatko and Herbert J. Fromm. He then completed a postdoctoral fellowship with Elizabeth A. Craig in Biochemistry at the University of Wisconsin–Madison. Professor Hines has won numerous awards for teaching and research, including being named a Cottrell Scholar by the Research Corporation for Science Advancement and a Henry-Dreyfus Teacher-Scholar by the Camille and Henry Dreyfus Foundation. He is also the author of the case-studies series for Macmillan’s three biochemistry textbooks. He enjoys running, hiking, games of any kind, and spending time with his wife and children.

Catherine Reinke

Catherine Reinke is an Associate Professor of Biology at Linfield University, where she teaches principles of biology, genetics, molecular cell biology, and animal development courses and conducts research with undergraduates. Her research interests include deciphering molecular mechanisms of gene regulation. She earned her BA in Biology and English from Carleton College, where she studied the regulation of inflorescence development with Susan Singer, and her PhD in Molecular Genetics and Cell Biology from the University of Chicago, where she studied mechanisms of endoplasmic reticulum inheritance and Golgi biogenesis with Benjamin Glick. After her introduction to teaching at Carleton College, she completed a postdoctoral fellowship with Richard Carthew in the Department of Molecular Biosciences at Northwestern University, where she studied molecular mechanisms of microRNA-mediated gene silencing. She is a recipient of the Laurence McKinley Gould Prize in Natural Science from Carleton College. She is also an active collaborator and principal investigator in the Genomics Education Partnership. She enjoys time spent with old friends and exploring new and cherished destinations with her husband John and children, Isaac and Ezra.

John L. Tymoczko

John L. Tymoczko was Towsley Professor of Biology Emeritus at Carleton College, where he taught from 1976 until his death in 2019. He taught a variety of courses, including Biochemistry, Biochemistry Laboratory, Oncogenes and the Molecular Biology of Cancer, and Exercise Biochemistry, and cotaught an introductory course, Energy Flow in Biological Systems. Professor Tymoczko received his B.A. from the University of Chicago in 1970 and his PhD in Biochemistry from the University of Chicago with Shutsung Liao at the Ben May Institute for Cancer Research. He then had a postdoctoral position with Hewson Swift of the Department of Biology at the University of Chicago. The focus of his research was on steroid receptors, ribonucleoprotein particles, and proteolytic processing enzymes.

Achieve for Biochemistry: A Short Course 5th Edition is an online learning system backed by extensive development and research. Proven to increase student engagement and boost performance. Achieve offers:

Access to the ebook to download, read and virtually annotate for a completely flexible experience.
Course and book-specific resources including adaptive quizzing to personalise the experience for students.
A grade book, assignable assessments with targeted feedback, insights and reporting, instructor resources - all with seamless integration options.
Integrated with iClicker so that instructors and students can benefit in class and remotely from an industry leading student response system.
Skills You Need Activities refresh prerequisite concepts to prepare students for upcoming chapters.
Online Autograded Homework with End-of-Chapter questions, offering answer-specific feedback and solutions, plus a vast Question Bank for customized assignments.
Interactive Figures and Animated Technique Videos bring protein structures and lab techniques to life.
Interactive Metabolic Map provides a dynamic exploration of metabolic pathways, with options to simulate different states (e.g., fed, fasting, diabetic) and their effects.

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About Achieve

Achieve is our online learning system backed by extensive development and research. Proven to increase student engagement and boost performance. Achieve offers:

Access to the ebook to download, read and virtually annotate for a completely flexible experience
Course and book-specific resources including adaptive quizzing (Learning Curve) to personalise the experience for students
A grade book, assignable assessments with targeted feedback, insights and reporting, instructor resources - all with seamless integration options.

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