Lehninger Principles of Biochemistry

Eighth Edition

Publication Date: March 16, 2021

Paperback ISBN: 9781319381493

Pages: 1248

The authoritative reference written with a framework for understanding.

Lehninger Principles of Biochemistry 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the...

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Preface viii
1. The Foundations of Biochemistry

I STRUCTURE AND CATALYSIS
2. Water, the Solvent of Life
3. Amino Acids, Peptides, and Proteins
4. The Three-Dimensional Structure of Proteins
5. Protein Function
6. Enzymes
7. Carbohydrates and Glycobiology
8. Nucleotides and Nucleic Acids
9. DNA-Based Information Technologies
10. Lipids
11. Biological Membranes and Transport
12. Biochemical Signaling

II BIOENERGETICS AND METABOLISM
13. Introduction to Metabolism
14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
15. The Metabolism of Glycogen in Animals
16. The Citric Acid Cycle
17. Fatty Acid Catabolism
18. Amino Acid Oxidation and the Production of Urea
19. Oxidative Phosphorylation
20. Photosynthesis and Carbohydrate Synthesis in Plants
21. Lipid Biosynthesis
22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
23. Hormonal Regulation and Integration of Mammalian Metabolism

III INFORMATION PATHWAYS
24. Genes and Chromosomes
25. DNA Metabolism
26. RNA Metabolism
27. Protein Metabolism
28. Regulation of Gene Expression Abbreviated Solutions to Problems
Glossary

‘Chemical Logic’ discusses the common biochemical reaction types that underlie all metabolic reactions, helping students to connect organic chemistry with biochemistry, and ‘Chemical Logic Figures’ highlight the conversation of mechanisms and illustrate patterns that make learning pathways easier. (Provided for each of the central metabolic pathways.)
Strong on visualization including ‘Clear Art’ molecular structures created specifically for Lehninger to keep consistency with color and shape schemes, understandable figures which include numbers with annotated steps to explain complex processes, mechanism figures features step-by-step descriptions to help students understand the reaction process and summary figures to help students keep the big picture in mind while learning the specific.
This text has an emphasis on problem solving with in text ‘Worked Examples’ that take students through particular difficult equations to improve their quantitative problem-solving skills, and data ‘Analysis Problems’ that encourage students to synthesize what they have learned and apply their knowledge to the interpretation of data from the literature. More than 600 end-of-chapter problems (all available in Achieve) are also included to give students further opportunity to practice what they have learned.
Tools for understanding are provided including ‘Key Conventions’ and ‘Special Themes’ (Metabolic Integration, Obesity, and Diabetes, Evolution) as well as ‘Medical Insights and Applications-Icons’ used throughout the book denote material of special medical interest and updated to reflect the most current content.
‘Skills You Need’ activities support students with review and practice of prerequisite skills and concepts from chemistry, biology, and math for each biochemistry chapter.

Achieve is Macmillan Learning’s complete online learning system. It houses instructor resources to support teaching and a range of interactive resources and the full e-textbook to help students succeed in their course. Access to Achieve for instructors is available on this page. Student access to Achieve could be through their institution if the institution has signed a license or as a separate student purchase. The instructor must set up a course for students to benefit from this product.

This edition has been fully updated for focus, approachability, up-to-date content and to efficiently support student study. New and updated end-of-chapter questions are all available in the Achieve problem library with error-specific feedback and thorough solutions. These questions went through a rigorous development process to ensure they were robust, engaging and accurate.
All content has been streamlined so the text is focused on what is most important and useful to modern students and for future reference, and organized around principles for better understanding, providing a new learning path for students, through the emphasis on the fundamental principles of biochemistry.
This edition has also been streamlined for easier navigation. This is evident in the new, vibrant design which improves navigation through the content, and the carefully trimmed topics and subtopics to emphasize crucial content, resulting in shorter chapters and an overall reduction in book length, as based on extensive user feedback.

David L. Nelson

David L. Nelson, born in Fairmont, Minnesota, received his BS inchemistry and biology from St. Olaf College in 1964, and earned his PhD inbiochemistry at Stanford Medical School, under Arthur Kornberg. He was apostdoctoral fellow at the Harvard Medical School with Eugene P. Kennedy,who was one of Albert Lehninger’s first graduate students. Nelson joinedthe faculty of the University of Wisconsin–Madison in 1971 and became afull professor of biochemistry in 1982. For eight years he was Director ofthe Center for Biology Education at the University of Wisconsin–Madison. Hebecame Professor Emeritus in 2013. Nelson’s research focused on the signaltransductions that regulate ciliary motion and exocytosis in the protozoanParamecium. For 43 years he taught (with Mike Cox) an intensive survey ofbiochemistry for advanced biochemistry undergraduates in the life sciences.He has also taught graduate courses on membrane structure and function, aswell as on molecular neurobiology. He has received awards for hisoutstanding teaching, including the Dreyfus Teacher–Scholar Award and theAtwood Distinguished Professorship. In 1991–1992 he was a visitingprofessor of chemistry and biology at Spelman College. Nelson’s second loveis history, and in his dotage he teaches the history of biochemistry andcollects antique scientific instruments.

Michael Cox

Michael M. Cox was born in Wilmington, Delaware. In his first biochemistry course, the first edition of Lehninger's Biochemistry was a major influence in refocusing his fascination with biology and inspiring him to pursue a career in biochemistry. After graduate work at Brandeis University with William P. Jencks and post-doctoral work at Stanford with I. Robert Lehman, he moved to the University of Wisconsin–Madison in 1983. He became a full professor of Biochemistry in 1992.

Mike Cox has coordinated an active research team at Wisconsin investigating the function and mechanism of enzymes that act at the interface of DNA replication, repair, and recombination. That work has resulted in over 200 publications to date.

For more than three decades, Cox has taught introductory biochemistry to undergraduates and has lectured in a variety of graduate courses. He organized a course on professional responsibility for first-year graduate students and established a systematic program to draw talented biochemistry undergraduates into the laboratory at an early stage of their college career. He has received multiple awards for both his teaching and his research, including the Eli Lilly Award in Biological Chemistry, election as an AAAS fellow, and the UW Regents Teaching Excellence Award. Cox's hobbies include turning 18 acres of Wisconsin farmland into an arboretum, wine collecting, and assisting in the design of laboratory buildings.

Achieve for Lehninger Principles of Biochemistry 8e is an online learning system backed by extensive development and research. Proven to increase student engagement and boost performance. Achieve offers:

Access to the ebook to download, read and virtually annotate for a completely flexible experience.
Course and book-specific resources including adaptive quizzing to personalise the experience for students.
A grade book, assignable assessments with targeted feedback, insights and reporting, instructor resources - all with seamless integration options.
Integrated with iClicker so that instructors and students can benefit in class and remotely from an industry leading student response system.
The ‘Interactive Metabolic Map’ allows students to navigate and zoom between overviews and detailed views of the most commonly taught metabolic pathways. Embedded Tours take students through the pathways step-by-step, helping them to both visualize concepts in isolation and understand how concepts are connected. By examining the pathways in this way, students are better equipped to understand the meaning of those connections.
‘Case Studies’ introduce students to a biochemical mystery and allows them to determine what investigations will solve it. Accompanying assessments ensure that students have fully completed and understood the case study, showing that they have applied their knowledge of the concepts.
‘Animated Mechanisms’ have been designed to enhance lecture or student study and help with visualization.
‘Animated Techniques’ include short animations of laboratory techniques. Designed to provide students with an overview of protocol, these animations give students a conceptual understanding of what is happening at the chemical level.
‘Problem Solving Videos’ with diagrams, graphs and narration, these videos walk students through problems on difficult topics helping them understand the right approach to the solution.

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